CAPA-IVM vs Standard IVM for Infertility
(IO-CAPA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This prospective study compares two approaches to obtaining mature oocytes for fertility treatment within the same participant. Immature oocytes are first retrieved from the right ovary and matured in the laboratory using a two-step biphasic capacitation in vitro maturation method (CAPA-IVM). Beginning on Day 5 of the same menstrual cycle, the left ovary undergoes minimal controlled ovarian stimulation followed by routine oocyte retrieval and IVF/ICSI.
The primary objective is to evaluate the maturation of CAPA-IVM oocytes to the metaphase II (MII) stage and compare reproductive laboratory outcomes between the CAPA-IVM and minimal-stimulation OS-IVF approaches. Secondary outcomes include fertilization, embryo development, blastocyst formation, embryo quality, pregnancy and live birth outcomes, and safety.
Who Is on the Research Team?
John J Zhang, M.D. Ph.D
Principal Investigator
New Hope Fertility Center
Are You a Good Fit for This Trial?
This trial is for women experiencing infertility who are undergoing fertility treatment. Participants must be able to provide immature eggs from both ovaries and have no major health issues that would prevent participation.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- CAPA-IVM
- Minimal-Stimulation OS-IVF
Trial Overview
The study compares two methods of maturing eggs for IVF: a lab-based method called CAPA-IVM using immature eggs from one ovary, versus standard minimal-stimulation IVF with eggs from the other ovary in the same woman.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
All participants undergo a within-patient comparison in the same menstrual cycle. The right ovary undergoes retrieval of immature oocytes for CAPA-IVM beginning on or after menstrual cycle Day 3, before ovarian stimulation. The left ovary subsequently undergoes minimal controlled ovarian stimulation beginning on Day 5, followed by oocyte retrieval and standard IVF/ICSI. Outcomes are compared according to ovary and oocyte origin, with each participant serving as her own internal control.
Find a Clinic Near You
Who Is Running the Clinical Trial?
New Hope Fertility Center
Lead Sponsor
Embryotools
Collaborator
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