Hormone-Free Egg Retrieval for Infertility
(HARVEST Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is testing whether eggs can be collected from small follicles without using the usual ovarian stimulation medications. Participants will have up to three egg retrieval procedures. The eggs collected during each retrieval will be matured in the laboratory using the CAPA-IVM (Capacitation In Vitro Maturation) process, fertilized, grown into embryos, and tested to identify chromosomally normal embryos.
Embryos from the retrievals may be frozen and accumulated. If a suitable embryo is available, one chromosomally normal embryo may be transferred. The study will also monitor safety, hormone levels, follicle development, embryo development, pregnancy results, and how well participants tolerate the study procedures.
Who Is on the Research Team?
Kevin Doody, MD
Principal Investigator
CARE Fertility Texas
Are You a Good Fit for This Trial?
This trial is for people experiencing infertility who want to try having a baby using IVF, but without taking hormone stimulation medications. Participants should be able to undergo egg retrieval procedures and embryo transfer.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Oocyte Retrieval and CAPA-IVM
Participants undergo up to three unstimulated transvaginal oocyte retrievals, followed by CAPA-IVM, ICSI, blastocyst culture, and PGT-A testing.
Embryo Transfer
Single euploid embryo transfer if a suitable embryo is available.
Follow-up
Participants are monitored for safety, hormone levels, follicle development, embryo development, and pregnancy results.
What Are the Treatments Tested in This Trial?
Trial Overview
The study tests collecting eggs from small follicles without hormones, maturing them in the lab (CAPA-IVM), fertilizing with ICSI, growing embryos, testing for normal chromosomes (PGT-A), freezing embryos, and transferring one healthy embryo if available.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants will undergo up to three unstimulated transvaginal oocyte retrievals targeting visible 4-9 mm antral follicles, without ovarian stimulation or ovulatory trigger medication. Retrieved oocytes will undergo CAPA-IVM (Capacitation In Vitro Maturation), ICSI (Intracytoplasmic Sperm Injection), blastocyst culture, PGT-A (Preimplantation Genetic Testing for Aneuploidy), embryo vitrification/accumulation, and single euploid embryo transfer if a suitable embryo is available.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Kevin Doody
Lead Sponsor
Lavima Fertility
Collaborator
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