Cooling Devices for Hyperthermia

Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Stanford University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to identify a blood test that detects signs of heat strain in the body and to evaluate devices that aid in cooling. Participants will engage in treadmill exercises in a lab setting and will use either a cooling bandana during exercise or a hand cooling table after exercise. Individuals who regularly exercise and are in good general health, without heart, kidney, or lung diseases, may be suitable candidates for this trial. As an unphased trial, this study provides participants the chance to contribute to innovative research that could lead to new methods for managing heat strain.

Do I have to stop taking my current medications for the trial?

Yes, you will need to stop taking medications that affect temperature or inflammation, like steroids or NSAIDs, to participate in the trial.

What prior data suggests that these cooling devices are safe for use in humans?

Studies have shown that cooling bandanas are safe and do not cause negative side effects. They cool the body through evaporation, making them easy to use in hot weather or during physical activity. Made from safe materials, these bandanas are convenient and effective.

Hand cooling tables are also safe for use after exercise. They lower body temperature by cooling the hands and forearms, effectively reducing body heat without harm.

Both cooling bandanas and hand cooling tables have been used in various situations without reports of serious side effects. They are designed to manage body heat safely during and after exercise.12345

Why are researchers excited about this trial?

Researchers are excited about these cooling techniques because they offer a non-invasive way to manage hyperthermia, which is a common challenge for athletes and individuals exposed to high temperatures. Unlike traditional methods such as medications or rest, these techniques use physical cooling devices like a bandana and a hand cooling table to help regulate body temperature. The cooling bandana provides direct cooling during exercise, while the hand cooling table aids in recovery. This trial could reveal how effective these devices are in quickly and safely bringing down body temperature, potentially offering a practical solution for managing heat-related stress.

What evidence suggests that these cooling devices are effective for hyperthermia?

This trial will evaluate the effectiveness of two cooling methods for managing heat during physical activity: cooling bandanas and hand cooling tables. Studies have shown that cooling bandanas, which use special materials, can effectively reduce body heat by lowering the core temperature by about 0.3°C per minute, providing quick relief. Similarly, research suggests that cooling the palms with hand cooling tables can also lower core temperature after exercise. Known as palmar cooling, this method has been linked to better recovery and reduced body temperature. Participants in this trial will experience both methods to assess their effectiveness.16789

Who Is on the Research Team?

JP

Julie Parsonnet, MD

Principal Investigator

Stanford University

Are You a Good Fit for This Trial?

This trial is for healthy adults who can safely participate in lab-based heat and exercise tests. People with health conditions that make it unsafe to be exposed to heat or do physical activity cannot join.

Inclusion Criteria

I am between 18 and 50 years old.
Able to communicate in English or Spanish
General good health
See 2 more

Exclusion Criteria

I am unable to give informed consent for my treatment.
I work directly for the study directors or in their laboratory.
I am currently taking steroids or anti-inflammatory medications.
See 7 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week

Biomarker Testing

Participants undergo biomarker testing to detect signs of heat strain

3 days
3 visits (in-person)

Cooling Intervention

Participants test cooling technologies including a cooling bandana and hand cooling table

3 days
3 visits (in-person)

Follow-up

Participants are monitored for any delayed effects of the interventions

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Cooling bandana
  • Hand cooling table

Trial Overview

Researchers are testing two cooling devices—a cooling bandana and a hand-cooling table—to see how well they help people cool down during simulated hot working conditions. They are also looking for blood markers that show signs of heat strain.

How Is the Trial Designed?

6

Treatment groups

Experimental Treatment

Group I: Hand cooling table (C), Cooling bandana (B), Biomarker testing (A)Experimental Treatment2 Interventions
Group II: Hand cooling table (C), Biomarker testing (A), Cooling bandana (B)Experimental Treatment2 Interventions
Group III: Cooling bandana (B), Hand cooling table (C), Biomarker testing (A)Experimental Treatment2 Interventions
Group IV: Cooling bandana (B), Biomarker testing (A), Hand cooling table (C)Experimental Treatment2 Interventions
Group V: Biomarker testing (A), Hand cooling table (C), Cooling bandana (B)Experimental Treatment2 Interventions
Group VI: Biomarker testing (A), Cooling bandana (B), Hand cooling table (C)Experimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials
2,527
Recruited
17,430,000+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials
2,513
Recruited
4,366,000+

Citations

Cooling Solutions for Hyperthermia · Info for Participants

Research has shown that cooling bandanas, which use special cooling materials, effectively and safely provide relief from heat. Once soaked in water, they can ...

Cooling Techniques for Hyperthermia - StatPearls - NCBI - NIH

Cooling measures may be applied safely and effectively using equipment commonly available in the emergency department and selected prehospital ...

Cooling Techniques for Hyperthermia

It was reported in volunteers that it reduces core body temperature by approximately 0.3°C per minute; it reduced core body temperature ...

Current and Future Cooling Technologies Used in Preventing ...

Few data showing the effectiveness of cooling methods were found. Subjective ratings of perceived exertion were reportedly lowered with use ...

First Aid Cooling Techniques for Heat Stroke and Exertional ...

Outcomes: Mortality and rate of body temperature reduction (°C/min or °C/hour) were ranked as critical outcomes. Clinically important organ ...

Cooling bandana

Soak the bandana for five to nine minutes and stay cool for up to 72 hours. It keeps you cool through evaporation. The bandana features a ...

7.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/16341523/

Safe cooling limits from exercise-induced hyperthermia

The objective of the study was to compare the three indices of core temperature and define safe cooling limits when using rectal temperature to avoid the ...

NCT06998667 | Cooling Solutions for Outdoor Workers

The investigators plan to test whether two active cooling technologies can help mitigate hyperthermia and risk for kidney injury.

Heat Stress Solutions & Technology

Cooling Bandana Headband: Crafted with advanced PVA cooling technology, this lightweight headband provides up to four hours of cooling relief. ...