Corn and Avocado Oils for High Cholesterol
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how corn and avocado oils might help lower cholesterol levels. Participants will follow a specific diet that includes these oils to assess their impact on heart health. The trial targets individuals with mildly to moderately high cholesterol who can adhere to a controlled diet and attend clinic check-ups. Participants should not have diabetes or heart disease and must consume only the foods provided during the trial periods. As an unphased trial, this study offers a unique opportunity to contribute to understanding dietary impacts on cholesterol.
Do I need to stop taking my current medications for the trial?
The trial requires that you do not change the dosage or start new medications that affect cholesterol or lipid levels within 12 weeks before the trial starts. Some specific medications and supplements must be stopped 2 to 12 weeks before the trial, depending on the type. It's best to discuss your current medications with the study team to see if any changes are needed.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Past studies have shown that corn oil lowers cholesterol levels with few problems. It reduces bad cholesterol (LDL) and total cholesterol. Reports indicate that people generally tolerate corn oil well in their diet, with no significant side effects noted.
Research also suggests that avocado oil is safe. Studies show it can lower bad cholesterol (LDL) and is rich in healthy fats. People usually handle avocado oil well, with no major side effects reported.
Both oils have been studied for their cholesterol-lowering abilities. Previous research suggests they are safe and well-tolerated by most people.12345Why are researchers excited about this trial's treatments?
Researchers are excited about using corn and avocado oils for managing high cholesterol because these oils offer a natural alternative to traditional medications like statins. Unlike standard treatments that often work by inhibiting cholesterol production in the liver, these oils are rich in unsaturated fats, which can help lower LDL cholesterol levels naturally. Furthermore, incorporating these oils into everyday foods like yogurt, dinner rolls, and muffins makes them an easy addition to daily diets, potentially improving adherence and overall heart health.
What evidence suggests that this trial's treatments could be effective for high cholesterol?
This trial will compare the effects of corn oil and avocado oil on cholesterol levels. Research has shown that both oils can help lower cholesterol, which is crucial for heart health. Participants in the corn oil arm will receive corn oil, which studies have found can reduce "bad" cholesterol (LDL) by about 10.9% and total cholesterol by 8.2%. Corn oil contains phytosterols, substances that help block cholesterol absorption in the body. Participants in the avocado oil arm will receive avocado oil, which also lowers LDL and total cholesterol. Additionally, avocado oil reduces inflammation, benefiting heart health. Overall, both oils show promise for improving cholesterol levels and reducing heart-related risks.12467
Are You a Good Fit for This Trial?
This trial is for men and women aged 18-74 who are generally healthy but have mildly to moderately high cholesterol. Participants must have a BMI between 18.5 and under 35, specific cholesterol levels, be able to visit the clinic regularly, and agree to eat only study-provided foods during each diet phase.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline
Participants undergo baseline assessments before starting the diet conditions
Diet Condition 1
Participants consume a controlled feeding diet with corn oil for 21 days
Washout
Participants return to their regular diet for a 21-day washout period
Diet Condition 2
Participants consume a controlled feeding diet with avocado oil for 21 days
Follow-up
Participants are monitored for safety and effectiveness after the diet conditions
What Are the Treatments Tested in This Trial?
Interventions
- Avocado Oil
- Corn Oil
Trial Overview
The study compares how corn oil versus avocado oil in controlled diets affects heart health risk factors in people with high cholesterol. Each participant tries both oils for three weeks each, separated by a break where they return to their usual diet.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Corn oil (4 tablespoons/d) will be provided in 3 servings of study products per day (yogurt, dinner roll, and muffin).
Avocado oil (4 tablespoons/d) will be provided in 3 servings of study products per day (yogurt, dinner roll, and muffin).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Midwest Center for Metabolic and Cardiovascular Research
Lead Sponsor
ACH Food Companies, Inc.
Industry Sponsor
Citations
I Switched to Avocado Oil—Here's What Happened to My ...
It's High in Monounsaturated Fats · It Contains Antioxidants · It May Lower LDL Cholesterol.
Effect of Avocado Consumption on Risk Factors of ... - PMC - NIH
The avocado diet was associated with decreased LDL levels, but it did not significantly impact triglyceride (TG) levels or fasting glucose levels.
Is avocado beneficial for lipid profiles? An umbrella review ...
Avocado intake was associated with significant reductions in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c), particularly in individuals ...
Evidence-Based Health Benefits of Avocado Oil
Another rat study found that avocado oil was effective in reducing levels of triglycerides and LDL (bad) cholesterol and did not affect HDL (good) cholesterol.
Avocado Oil Supplementation Modifies Cardiovascular Risk ...
Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed. These findings suggested that avocado oil supplementation ...
Avocado Oil vs. Olive Oil: Benefits and Drawbacks
Avocado and olive oil are also both low in saturated fats, which may raise cholesterol levels when consumed in excess. Here's a comparison of ...
Avocado Consumption and Risk of Cardiovascular ...
Higher avocado intake was associated with lower risk of CVD and coronary heart disease in 2 large prospective cohorts of US men and women.
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