High Fiber Program for Cancer Patients Undergoing Transplant

This trial explores whether a High Fiber Program can increase fiber intake in patients preparing for a stem cell transplant. The goal is to improve gut health and potentially prevent complications like GVHD, where donor cells attack the recipient's body. Participants will attend several sessions with a dietitian to learn about high-fiber foods and how to incorporate them into their diet. Those planning to undergo a stem cell transplant soon and able to manage a fiber-rich diet might be suitable candidates. As an unphased trial, it offers a unique opportunity to contribute to research that could enhance transplant outcomes.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor to get a clear answer based on your specific situation.

Research has shown that a high-fiber diet may benefit patients who have undergone stem cell transplants. One study found that patients who consumed more fiber before and after their transplant experienced better survival rates and a lower risk of gut issues, such as GVHD (graft versus host disease). GVHD occurs when new cells attack the body's healthy cells, leading to symptoms like skin rashes or dry eyes.

Unlike the standard of care for cancer patients undergoing transplant, which typically focuses on managing symptoms and preventing complications with medications and dietary supplements, the High Fiber Program uses a dietary approach to potentially improve patient outcomes. Researchers are excited about this trial because it involves regular dietitian-led counseling sessions and a specialized "Fiber Aware Menu" that integrates high fiber foods into the patients’ diet. This approach aims to enhance gut health, which could support immune function and recovery post-transplant, offering a non-invasive and holistic method that differs from traditional medical treatments.

Research has shown that a high-fiber diet can benefit individuals undergoing allogeneic hematopoietic cell transplant (HCT). Studies have found that patients consuming more fiber tend to live longer and face a lower risk of graft versus host disease (GVHD), a common post-transplant issue. Specifically, one study discovered that a high-fiber diet correlates with a healthier gut and a reduced chance of severe GVHD in the digestive system. Additionally, patients on high-fiber diets have experienced slower disease progression and better treatment responses. This trial will evaluate the High Fiber Program, where participants will attend dietitian-led counseling sessions and follow a fiber-rich diet. These findings suggest that increasing fiber intake may enhance gut health and overall outcomes for HCT patients.¹⁶⁷⁸⁹