Digital Outreach for Congestive Heart Failure

(ADHERE-HF Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Kaiser Permanente
Must be taking: GDMT medications
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether digital outreach, such as text messages or automated phone calls, can help people with heart failure adhere to their medication schedules. It specifically examines whether these reminders increase the likelihood of refilling overdue heart failure medications compared to standard care without reminders. Individuals with heart failure who have not refilled a prescription for 7-13 days may be suitable candidates for this trial. As an unphased study, this trial provides a unique opportunity to contribute to innovative solutions that could enhance medication adherence for heart failure patients.

What prior data suggests that this digital outreach is safe for heart failure patients?

Research has shown that digital tools, such as interactive text messages and automated phone calls, are well-received in heart failure care. These tools assist patients in taking their medication regularly and improving their health. They are safe because they emphasize communication rather than medication or medical procedures.

For example, studies have found that telehealth, similar to digital outreach, has reduced hospital visits and death rates in heart failure patients. This suggests that digital outreach is generally safe and effective for managing heart failure.

In summary, digital outreach offers a safe and non-invasive method to help heart failure patients adhere to their medication and enhance their health.12345

Why are researchers excited about this trial?

Researchers are excited about Digital Outreach for congestive heart failure because it introduces a tech-savvy twist to managing the condition. Unlike traditional treatments that rely heavily on in-person consultations and medication adjustments, this approach uses interactive text messages or automated phone calls to remind patients to refill their overdue heart failure medications. This method aims to improve medication adherence, potentially leading to better health outcomes without the need for more frequent hospital visits. By leveraging digital communication, the treatment offers a more convenient and accessible way for patients to stay on top of their heart health, which is particularly appealing in our increasingly connected world.

What evidence suggests that digital outreach is effective for improving medication adherence in heart failure patients?

Research has shown that digital methods like text messages and automated calls can help people remember to refill their medications. In this trial, participants in the Digital Outreach arm will receive interactive text messages or automated phone calls to encourage the refill of overdue heart failure medications. Studies have found that these digital reminders help patients stay on track with their medications. This is particularly beneficial for individuals with heart failure, as regular medication adherence is crucial for managing their condition. Early results suggest that interactive reminders can be more engaging and lead to better health outcomes than standard care. Although specific data for heart failure patients is limited, the success of this strategy in other health areas strongly supports its use.678910

Are You a Good Fit for This Trial?

This trial is for adults with heart failure who are overdue for refilling a prescribed heart failure medication. Participants must be part of a health system that uses digital communication, like text messages or automated calls.

Inclusion Criteria

Active KPNC membership
At least one unfilled refill for an eligible GDMT medication that is 7-13 days overdue at index
I have been taking at least one approved heart failure medication for 6 months or more.
See 3 more

Exclusion Criteria

Skilled nursing facility stay within prior 12 months
No valid telephone number on file through which the patient could be reached by text message or automated telephone call
Other conditions that prevent outreach
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Digital Outreach

Participants receive interactive text messages or automated phone calls encouraging refill of overdue heart failure medications

12 months

Follow-up

Participants are monitored for medication adherence, refill rates, and clinical outcomes such as heart failure hospitalization and mortality

12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Digital Outreach

Trial Overview

The study tests if sending interactive text messages or automated phone calls helps people with heart failure refill their medications on time compared to those receiving usual care without extra reminders. Participants are randomly assigned to either group.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Digital OutreachExperimental Treatment1 Intervention
Group II: Usual CareActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Kaiser Permanente

Lead Sponsor

Trials
563
Recruited
27,400,000+

Citations

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(PDF) The Digital Future of Heart Failure Care

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The authors highlight that outcomes improve only when digital data are paired with defined workflows, clinician accountability, and rapid clinical response—such

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Among the 587 participants, those who received TC experienced reduced rates of all mortality and readmission within one year, as well as lower ...