Heart Biopsy for Heart Failure
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to study heart tissue changes in individuals with heart failure to aid in developing new treatments. It involves a heart biopsy, where a small tissue sample is taken during a procedure called right heart catheterization. Suitable candidates for this trial have symptoms of heart failure and a history of the condition, such as frequent shortness of breath or swelling, but maintain normal heart pumping function.
As a Phase 2 trial, it measures the treatment's effectiveness in an initial, smaller group, offering participants the opportunity to contribute to potentially groundbreaking heart failure therapies.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover the specific myocardial mechanisms involved in heart failure with preserved ejection fraction (HFpEF), a condition for which current treatments often provide limited relief. Unlike other trials that focus on testing new medications, this study dives deep into understanding how the heart's muscles and functions contribute to HFpEF. By identifying these unique mechanisms, the trial could pave the way for developing more targeted therapies that address the root causes of the condition, potentially offering more effective solutions for patients in the future.
Who Is on the Research Team?
Sanjiv Shah, MD
Principal Investigator
Northwestern University
Margaret Redfield, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Procedure
Participants undergo an endomyocardial biopsy (EMB) during a right heart catheterization (RHC) to identify changes in heart tissue structure and biological function
Follow-up
Participants are monitored for safety and effectiveness after the procedure
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
Northwestern University
Lead Sponsor
Brigham and Women's Hospital
Collaborator
University of Pennsylvania
Collaborator
Massachusetts General Hospital
Collaborator
Mayo Clinic
Collaborator
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Wake Forest University Health Sciences
Collaborator