Pulmonary Ultrasound for Heart Failure

Not yet recruiting at 1 trial location
EB
AG
Overseen ByAndrew Grandin
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Rutgers, The State University of New Jersey
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether lung ultrasound can help paramedics diagnose heart failure in patients with breathing problems more accurately. The study aims to determine if this tool improves diagnostic accuracy and patient outcomes. Participants will receive a lung ultrasound as part of their emergency care, and researchers will compare their results to those who did not receive the ultrasound due to logistical reasons. It suits individuals treated by emergency services who experience difficulty breathing and symptoms such as low oxygen levels or abnormal lung sounds. As an unphased trial, this study allows participants to contribute to research that could enhance emergency care for future patients.

Do I have to stop taking my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications. It seems like you will continue with your standard care, which likely includes your current medications.

What prior data suggests that pulmonary ultrasound is safe for diagnosing heart failure?

Research has shown that using ultrasound on the lungs is generally safe for diagnosing heart failure. Studies indicate that lung ultrasounds are non-invasive and do not use radiation, unlike some other imaging tests, making them less likely to cause harm.

Most people tolerate the procedure well, with very few reports of unexpected medical problems. The ultrasound device uses sound waves to create images, a common practice in medical settings. These sound waves are safe and have been used for many years in other types of medical imaging, such as pregnancy scans.

In conclusion, lung ultrasound is considered a safe and well-tolerated option for assessing heart conditions.12345

Why are researchers excited about this trial?

Researchers are excited about using pulmonary ultrasound for heart failure because it offers a non-invasive and quick way to assess fluid levels in the lungs, which is crucial for managing this condition. Unlike traditional methods like chest X-rays or CT scans that can take longer and expose patients to radiation, ultrasounds can be done bedside and provide immediate results. This real-time feedback can help doctors make faster and more accurate treatment decisions, potentially improving patient outcomes and reducing hospital stays.

What evidence suggests that pulmonary ultrasound is effective for diagnosing heart failure?

Research has shown that lung ultrasound is a powerful tool for diagnosing heart failure. Studies indicate it surpasses chest X-rays in detecting lung fluid, a heart failure indicator. One study found that lung ultrasound reduced the time to start treatment to just 26 minutes, compared to 110 minutes without it. This trial will include patients who receive ultrasound and those who do not, to evaluate its effectiveness in real-world settings. This approach allows patients to receive faster and potentially more accurate care. Additionally, lung ultrasound is non-invasive, as it doesn't involve surgery or needles, making it a safe option for assessing heart failure.12467

Who Is on the Research Team?

DL

Danielle Levine, MD

Principal Investigator

Christiana Care Health Services

SC

Stephen Carroll, DO, MEd

Principal Investigator

Christiana Care Health Services

TY

Tung-Lin Yuan, DO

Principal Investigator

Rutgers University

Are You a Good Fit for This Trial?

This trial is for adults (18+) treated by EMS with breathing problems, low oxygen, abnormal lung sounds, leg swelling, or trouble lying flat. People are excluded if their symptoms are from trauma, they had cardiac arrest before hospital arrival, no ultrasound-trained paramedic was present, or they're under 18.

Inclusion Criteria

Patient treated by Emergency Medical Services
I have at least one breathing or lung problem, like low oxygen or trouble breathing.
I have trouble breathing or feel short of breath.

Exclusion Criteria

Traumatic etiology
Cardiac arrest at any point prehospitally
No ultrasound-trained paramedic involved in patient's care
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive a lung ultrasound exam and standard evaluation and care

During emergency medical service encounter
1 visit (in-person)

Follow-up

Participants are monitored for diagnostic accuracy and outcomes until hospital discharge

1 week

What Are the Treatments Tested in This Trial?

Interventions

  • Pulmonary Ultrasound

Trial Overview

The study tests whether using a lung ultrasound in the ambulance helps paramedics better diagnose heart failure and guides treatment. All patients get standard care; some also receive an ultrasound based on availability of trained staff.

How Is the Trial Designed?

3

Treatment groups

Active Control

Group I: Patients who receive ultrasoundActive Control1 Intervention
Group II: Patients before ultrasound implementationActive Control1 Intervention
Group III: Patients who do not receive ultrasoundActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Rutgers, The State University of New Jersey

Lead Sponsor

Trials
471
Recruited
81,700+

Christiana Care Health Services

Collaborator

Trials
118
Recruited
204,000+

Hackensack Meridian Health

Collaborator

Trials
141
Recruited
42,900+

Cooper University Health Care

Collaborator

Trials
2
Recruited
2,000+

Citations

Lung Ultrasound Offers Fast and Reliable Exclusion of Heart ...

These results suggest that LUS is particularly effective for ruling out acute heart failure (AHF) but may be less reliable for confirming ...

Lung ultrasound usefulness in heart failure

Lung ultrasound is more sensitive and specific than chest X-rays for detecting pulmonary oedema in patients with suspected acute heart failure [ ...

Lung Ultrasound in Acute Heart Failure: Prevalence of ...

Download article citation data for: Lung Ultrasound in Acute Heart Failure: Prevalence of Pulmonary Congestion and Short- and Long-Term Outcomes.

Pre‐Hospital Lung Ultrasound in Acute Heart Failure ...

Median time to treatment was 26 min (range 6–211 min) with LUS and 110 min (range 7–301) without LUS (p < 0.01). TABLE 1. Acute Heart Failure ...

Diagnostic significance of lung ultrasound in evaluation ...

Recent bicentric data confirm the high diagnostic performance of pulmonary ultrasonography for acute heart failure, reinforcing its role as a ...

Pulmonary Ultrasound in Patients with Heart Failure - PMC - NIH

Agreement of PU with the final diagnosis was 84%, with S = 86% and E = 87% for cardiac pulmonary edema, and IVC values > 9 mm on B mode had S = 84.4% and E = ...

Lung ultrasound-guided decongestion in heart failure ...

LUS enables more precise, bedside assessment of pulmonary congestion in HF patients. •. Findings support LUS as a promising adjunct in heart failure management ...