Curcumin, Omega-3, and Vitamin D Supplements for Healthy Subjects

(PASCOD3 Trial)

This trial explores whether a mix of curcumin, omega-3, and vitamin D supplements can lower levels of ACPA, an antibody linked to certain autoimmune conditions. Researchers aim to determine if these supplements are safe and well-tolerated. Participants will take the supplements daily for three months and record their experiences. Individuals with high ACPA levels who are willing to stop current supplement use for a month beforehand may be suitable candidates. As an unphased trial, this study provides a unique opportunity to contribute to understanding the potential benefits of these supplements for autoimmune conditions.

If you are currently taking vitamin D and/or omega-3 supplements, you will need to stop taking them before starting this trial. The protocol does not specify about other medications, so it's best to discuss your specific situation with the study team.

Research has shown that curcumin, omega-3, and vitamin D are generally safe for people. One study on curcumin found no harmful effects, suggesting regular use is safe. Omega-3 and vitamin D, common in supplements, are usually well-tolerated. Most people taking these supplements do not experience serious side effects, though mild issues like an upset stomach or nausea can occur. Overall, current evidence considers using these supplements together safe.¹²³⁴⁵

Researchers are excited about these treatments because they combine natural supplements like Theracurmin, a highly absorbable form of curcumin, with vitamin D and omega-3 fatty acids. Unlike standard supplements, Theracurmin has enhanced bioavailability, meaning the body can absorb it more effectively, potentially boosting its anti-inflammatory benefits. Moreover, these supplements collectively target inflammation and support overall health, which is different from conventional approaches that might rely on synthetic drugs. This combination may offer a holistic alternative to maintaining health, emphasizing natural ingredients and improved absorption.

Research has shown that taking curcumin, vitamin D, and omega-3 supplements together may lower the risk of developing diabetes in pre-diabetic individuals. One study found that a type of curcumin, when combined with vitamin D, effectively eases the onset of certain health issues. Curcumin and omega-3 fatty acids have also been studied for their potential to boost brain function by improving blood flow in the brain. While these studies suggest possible benefits, this trial specifically examines how Theracurmin, Vitamin D, and Omega-3 affect a certain antibody level, which remains unproven.¹³⁶⁷⁸