Thigh Cuffs for Fluid Shift in Healthy Subjects

This trial tests thigh cuffs to manage fluid shifts in astronauts during space missions. These Venoconstrictive Thigh Cuffs (VTC) aim to counteract fluid movement toward the head in weightlessness, potentially preventing eye issues known as SANS. Participants will experience different stages of wearing the cuffs before and during their flight. The trial suits astronauts on missions lasting two months or more, who do not have certain allergies or a high risk of blood clots. As an unphased trial, it offers astronauts a unique opportunity to contribute to innovative solutions for space health challenges.

The trial does not specify if you need to stop taking your current medications, but if you are using ethinyl estradiol Combined Oral Contraceptive (COC) pills, you cannot participate.

Research has shown that special thigh cuffs can help control fluid movement in the body during situations like space travel or long periods of bed rest. Studies suggest these cuffs do not pose significant medical risks. For example, one study found no major side effects when participants used these thigh cuffs to manage fluid movement.

Researchers are excited about using Venoconstrictive Thigh Cuffs (VTC) because they offer a novel approach to managing fluid shifts in the body, especially in unique environments like space. Unlike traditional methods that may rely on medications to manage fluid distribution, VTCs are a non-invasive, mechanical solution that can be worn to directly influence blood flow. This technique could potentially provide an immediate and adjustable way to counteract fluid shifts, which is particularly advantageous for astronauts experiencing prolonged periods in microgravity. The ability to study these effects in-flight offers a real-time understanding of the cuff's impact, making it a promising tool for space travel and possibly other applications on Earth.

Studies have shown that Venoconstrictive Thigh Cuffs (VTC) can help reduce the upward movement of body fluids that occurs in weightlessness, such as in space. This fluid movement can increase pressure in the head and eyes, causing problems for astronauts. Research indicates that the thigh cuffs work by gently squeezing the legs to prevent fluids from moving upward. Initial findings suggest that VTCs can reduce the swelling of the optic nerve sheath, a significant change during space travel. In this trial, participants will use VTCs to further evaluate their effectiveness in managing these fluid shifts and protecting astronauts' health in space.⁶⁷⁸⁹¹⁰