Olive Oil Extract for Knee Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether an olive oil extract can reduce knee pain and improve knee function in adults. Participants will take a daily capsule, either the olive oil extract or a placebo, for six weeks. Individuals who have experienced knee discomfort for at least three months and are willing to complete the study activities are ideal candidates. The goal is to determine if this natural supplement can significantly improve knee sensation and movement. As an unphased trial, it allows participants to contribute to understanding the potential benefits of a natural supplement for knee health.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you will need to record any pain medications you take during the study.
Is there any evidence suggesting that this treatment is likely to be safe for humans?
Studies have shown that olive oil extract, particularly from olive leaves, possesses properties that reduce swelling and protect cells from damage. This can help with inflammation and maintain cell health. Research indicates that individuals who took olive leaf extract daily reported less knee pain and improved movement. Importantly, olive leaf extract is generally well-tolerated, with no major reports of side effects in the available studies, suggesting it is safe for most people to use.12345
Why are researchers excited about this trial?
Unlike standard treatments for knee pain, such as NSAIDs or corticosteroid injections, the olive oil extract in this trial is derived from natural sources and contains bioactive compounds like oleocanthal and oleacein. These components are known for their anti-inflammatory properties, potentially offering pain relief without the side effects associated with conventional medications. Researchers are excited because this approach could provide a natural and holistic option for improving joint comfort and function, promoting general wellness.
What evidence suggests that olive oil extract might be an effective treatment for knee pain?
Research has shown that olive oil extract, particularly when it contains compounds like oleocanthal and oleacein, may improve joint comfort and movement. In this trial, participants will receive either an olive oil extract dietary supplement or a placebo. One study found that an olive leaf extract reduced pain and improved mobility in elderly individuals with knee osteoarthritis. Another study suggested that a supplement with oleuropein could enhance joint function in older adults with severe knee pain. However, some reports indicate that olive leaf extract did not significantly aid knee pain or movement in individuals without osteoarthritis. Overall, the evidence remains mixed, but there are positive signs, especially for those with severe knee pain.26789
Who Is on the Research Team?
Chad Kerksick, PhD
Principal Investigator
Are You a Good Fit for This Trial?
This trial is for adults aged 40 to 75 who have had knee discomfort for at least 3 months. Participants must be able to use digital devices, complete movement tasks, wear an activity tracker, collect saliva samples at home if needed, and take a daily capsule.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants take one assigned study capsule (supplement or placebo) daily with food for 6 weeks and complete digital questionnaires about knee pain, stiffness, and function.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including final assessments of knee pain, stiffness, and function.
What Are the Treatments Tested in This Trial?
Interventions
- Olive Oil Extract
Trial Overview
The study tests whether taking an olive oil extract supplement daily for 6 weeks can improve knee pain and function compared to a placebo. Participants are randomly assigned to either the olive oil extract or placebo group.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants randomized to this arm will receive an olive oil extract dietary supplement capsule taken once daily with food for 6 weeks. The supplement delivers olive-derived bioactive compounds (including oleocanthal and oleacein) and is intended for general wellness use related to joint comfort and function.
Participants randomized to this arm will receive a matched placebo capsule taken once daily with food for 6 weeks. The placebo is formulated to be similar in appearance, taste, and packaging to the investigational product but does not contain the active olive-derived bioactive compounds
Find a Clinic Near You
Who Is Running the Clinical Trial?
Applied Food Sciences Inc.
Lead Sponsor
Alethios, Inc.
Industry Sponsor
Citations
Impact of olive leaf extract on pain management and ...
Hydroalcoholic olive leaf extract effectively reduces pain and improves physical functioning in elderly patients with knee osteoarthritis.
An oleuropein-based dietary supplement may improve joint ...
An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and post ...
3.
nutraingredients.com
nutraingredients.com/Article/2022/03/10/olive-leaf-extract-can-relieve-severe-knee-pain-study-finds/Olive leaf extract can relieve severe knee pain, study finds
Study results indicate OLE at the posology tested had no significant effect on knee pain and function in subjects without osteoarthritis.
Examining Olive Oil Extract on Knee Comfort and Function
Overview. The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults.
5.
acrabstracts.org
acrabstracts.org/abstract/an-oleuropein-based-dietary-supplement-improves-joint-function-in-older-people-with-high-knee-joint-pain/An Oleuropein-based Dietary Supplement Improves Joint ...
Conclusion: OLE was not effective on joint discomfort in people with low to moderate pain at baseline but significantly benefited subjects with high pain at ...
Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive ...
Several in vitro and in vivo studies showed that olive leaf extract (OLE) has anti-inflammatory and antioxidant properties.
7.
drstanfield.com
drstanfield.com/blogs/articles/olive-leaf-extract-benefits-forms-dosing-and-side-effects?srsltid=AfmBOooq_HcrLOnJARkTVaa20cFFTjLPp4g6AGWfpCLbeQlhLPWowZ2COlive Leaf Extract: Benefits, Forms, Dosing, and Side Effects
... knee pain or joint function in the general population with moderate joint symptoms. ... safety data for olive leaf extract use during ...
8.
examine.com
examine.com/supplements/olive-leaf-extract/research/?srsltid=AfmBOoqDOsJhEIcmCXhjaOdxVUEqkiImKwmMHE9FWRghrEUZ1WJhT8TzResearch Breakdown on Olive Leaf Extract
Oleuropein, commonly seen as the main bioactive and in studies is commonly standardized to 18-22% of the supplement while consisting of around 60-90mg/g (6-9%) ...
Therapeutic Potential of Olive Leaf Extracts
This study aimed (i) to review evidence about the importance of olive leaf extract (OLE) on human health and the physiological effect of its major compounds.
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