Speed of Processing Training for Head and Neck Cancer Survivors

AS
HY
Overseen ByHon Yuen
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Alabama at Birmingham
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a game-based cognitive training called Speed of Processing Training to determine its effectiveness in improving reaction time and thinking skills in individuals who have had head and neck cancer. Participants will engage in video game exercises designed to enhance the speed and accuracy of information processing, which might also improve driving abilities. The study includes two groups: one will undergo the speed training, while the other will play non-challenging games for comparison. This trial suits those who have survived head and neck cancer, noticed changes in their thinking abilities, and are at least six months past their cancer treatment. As an unphased trial, it offers a unique opportunity to contribute to innovative research that could enhance cognitive recovery for cancer survivors.

What prior data suggests that this Speed of Processing Training is safe for head and neck cancer survivors?

Research shows that Speed of Processing Training (SOPT) is safe and well-tolerated by cancer survivors. Studies have found that similar brain training improves memory, attention, and thinking speed in childhood cancer survivors without causing significant side effects. For instance, training enhanced working memory and attention, indicating effectiveness with minimal risks. Additionally, breast cancer survivors who engaged in these mental exercises experienced improvements in verbal skills and thinking speed, underscoring the treatment's safety and potential benefits. Overall, current evidence supports that SOPT is safe for people recovering from cancer, with no major negative effects reported.12345

Why are researchers excited about this trial?

Most treatments for cognitive issues in head and neck cancer survivors focus on medication or traditional cognitive therapy. But Speed of Processing Training is unique because it involves game-based cognitive exercises that boost the speed and accuracy of visual information processing. Unlike typical treatments, this method enhances divided attention between central and peripheral stimuli, even with distractions, offering a more interactive and engaging approach. Researchers are excited about this training because it could provide a non-pharmacological option that is both effective and enjoyable for patients, potentially leading to significant improvements in cognitive function without the side effects of medication.

What evidence suggests that Speed of Processing Training is effective for improving cognitive functioning in head and neck cancer survivors?

Research has shown that Speed of Processing Training, which participants in this trial may receive, can help cancer survivors enhance their cognitive skills. Studies found that individuals who underwent this training processed information faster and improved their memory. Cancer survivors using speed training software also performed better on cognitive tasks. This suggests that the training might help head and neck cancer survivors react more quickly and think more clearly.678910

Who Is on the Research Team?

HY

Hon Yuen

Principal Investigator

University of Alabama at Birmingham

Are You a Good Fit for This Trial?

This trial is for adults who have survived head and neck cancer. Participants should be able to use a computer at home, complete questionnaires, and take part in simulated driving tests. People with conditions that would prevent them from safely participating may not be eligible.

Inclusion Criteria

Visual acuity of at least 20/40 using a Snellen eye chart
Functional hearing sufficient to engage in daily conversation in English for ≥ 15 minutes
My legs function well and I can walk quickly without assistance.
See 8 more

Exclusion Criteria

Anticipated life expectancy of < 6 months based on physician prognosis
Significant neurologic or psychiatric comorbidities, including psychotic disorders, bipolar disorders, Alzheimer's disease or related dementias, developmental disorders, seizure disorders, vestibular disorders, prior brain tumor or brain surgery, or poorly controlled metabolic disease
I am currently taking antipsychotic or mood-stabilizing medications.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants complete questionnaires and a driving assessment using a virtual reality driving simulator

1 week
1 visit (in-person)

Treatment

Participants engage in 30-minute video game-based cognitive exercises twice weekly for 10 weeks

10 weeks
20 sessions (home-based)

Post-Treatment Assessment

Participants complete cognitive assessments and a driving assessment similar to baseline

1 week
1 visit (in-person)

Follow-up

Participants are monitored for any long-term effects and outcomes

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Speed of Processing Training

Trial Overview

The study compares two types of home-based video game training over 10 weeks: one designed to improve thinking speed (Speed of Processing Training) and another sham version. The goal is to see if the special training helps reaction time and driving skills.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: Speed of Processing TrainingExperimental Treatment1 Intervention
Group II: Home-Based Sham TrainingPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alabama at Birmingham

Lead Sponsor

Trials
1,677
Recruited
2,458,000+

Citations

Psychological Intervention for Improving Cognitive ...

Results revealed participating in the intervention was associated with significantly faster performance on one objective cognitive task that measures processing ...

Cognitive Effects of Cancer and Cancer Treatments - PMC - NIH

Survivors randomized to use speed of processing training software (Brain HQ by Posit Science) improved their processing speed and memory, whereas those who ...

Protocol Effects of Semisupervised Exercise Training on ...

Exercise training has been shown to be safe and have positive effects on health outcomes in people with lung or head and neck cancer [15].

Computerized Cognitive Training Improves Childhood ...

Working memory improved significantly, and attention and processing speed also improved for childhood cancer survivors who completed between 20 ...

Computerized cognitive training improves childhood ...

Working memory improved significantly, and attention and processing speed also improved for childhood cancer survivors who completed between 20 ...

Breast Cancer Survivors' Executive Function Improves With ...

The results showed significantly larger gains in executive function, word finding, and processing speed; a progressive improvement in verbal ...

Improving Attention and Memory in Childhood Cancer ...

Working memory improved significantly, and attention and processing speed also improved for childhood cancer survivors who ...

Effects of Computer-Assisted Cognitive Rehabilitation ...

Effects of Computer-Assisted Cognitive Rehabilitation Programs With Breast Cancer Survivors. ClinicalTrials.gov ID NCT04027400.

QOS-09: EFFICACY OF COGNITIVE AND PHYSICAL ... - PMC

The cancer survivors will be randomly assigned to either a computerized memory training, a physical training, or a waiting control group. The pre ...

(PDF) Evaluating the Effectiveness of Visuospatial Memory ...

Twenty-two patients with head and neck cancer were enrolled in this pilot study to characterize their visuospatial memory capacity, a form of ...