BEAM Procedure for Obesity

(BEAM Trial)

This trial explores a new weight loss procedure called Bariatric Endoscopic Antral Myotomy (BEAM) to assess its effects on weight loss and gut health in individuals with obesity. Researchers aim to determine if this procedure, performed without another common surgery, can aid in weight loss and affect stomach function and hormones. Participants will either receive the BEAM procedure along with lifestyle changes or continue with lifestyle changes alone. The trial seeks participants currently involved in a weight management program, with a BMI between 30 and 50, who are approved for certain weight loss procedures. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research in weight loss treatments.

The trial requires that you stop taking any medications that may interfere with weight loss or gastric emptying.

Research shows that the Bariatric Endoscopic Antral Myotomy (BEAM) procedure holds promise for safety. One study examined its feasibility and safety, finding that patients generally tolerated it well. Another study reported significant weight loss, with patients losing an average of 9.1% at 6 months and 12.2% at 12 months. Importantly, these outcomes occurred without major safety issues. The studies primarily focus on ensuring the procedure's safety and effectiveness for weight loss, and the safety results have been positive so far.¹²³⁴⁵

The BEAM Procedure for obesity is unique because it combines an innovative technique called Bariatric Endoscopic Antral Myotomy (BEAM) with standard lifestyle modification therapy. Unlike traditional surgical options like gastric bypass or sleeve gastrectomy, BEAM is a less invasive endoscopic procedure that alters the stomach's function to help control hunger and promote weight loss. Researchers are excited about this approach because it could offer a safer, less invasive alternative to major surgery, potentially reducing recovery time and associated risks while still providing effective weight management.

Research has shown that Bariatric Endoscopic Antral Myotomy (BEAM), which participants in this trial may receive, can aid weight loss in people with obesity. In an initial study, patients who underwent this procedure lost about 12% of their total body weight within a year. The procedure slows the stomach's emptying process, potentially helping individuals feel full longer and eat less. This method resembles adding a stomach muscle cut to another weight-loss procedure and has shown promise in earlier trials. While early results are encouraging, further research is needed to confirm its long-term effectiveness.¹²³⁴⁵