Cocoa Flavanol Supplement for Vascular Health
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized, double-blind, controlled clinical trial will evaluate the effects of daily cocoa flavanol supplementation on vascular and inflammatory biomarkers in healthy adult men aged 30 to 75 years. Participants will be randomized to receive either a cocoa flavanol supplement or a nutrient-matched low-flavanol control product for 4 to 8 weeks. The study will assess changes in inflammatory biomarkers, endothelial function, oxidative stress markers, vascular measurements, and circulating endothelial progenitor cell-related markers. Optional assessments include flow-mediated dilation and single-cell RNA sequencing of peripheral blood mononuclear cells to explore mechanistic biological responses to cocoa flavanol supplementation.
Who Is on the Research Team?
Shlomi Brielle, PhD
Principal Investigator
The Black Forest LLC
Are You a Good Fit for This Trial?
This trial is for healthy men aged 30 to 75 years. Participants should not have major health problems and must be able to take a daily supplement for up to 8 weeks.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Cocoa Flavanol Supplement
Trial Overview
The study tests whether taking a daily cocoa flavanol supplement improves blood vessel health and reduces inflammation compared to a similar powder with low flavanols. Participants are randomly assigned to one of the two groups, and neither they nor the researchers know which group they're in.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Participants will receive a daily cocoa flavanol powder supplement providing approximately 1,200 mg total cocoa flavanols per day for 4 to 8 weeks. The supplement will be administered orally once daily in a blinded fashion.
Participants will receive a nutrient-matched low-flavanol cocoa-based powder containing less than 2% total flavanols for 4 to 8 weeks. The control product is designed to match the active supplement in appearance and administration while minimizing biologically active flavanol exposure.
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Black Forest LLC
Lead Sponsor
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