Self-Management Programs for Pain in Liver Cirrhosis
(ALLEVIATE-C Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to test a low-touch vs high-touch drug-free pain self-management program that may help lower pain and improve quality of life for adults with cirrhosis and pain. Participants are assigned by chance to one of two study groups. The groups receive different levels of support. The main questions it aims to answer are:
* Do the programs help lower pain?
* Do the programs improve quality of life?
* Is one program more effective than the other?
Researchers will compare a low-touch self management program to a high-touch self-management program to see if the programs help manage pain.
Participants in the low-touch arm will:
* Learn new ways to manage pain without medication
* Receive access to the self-guided digital self-management platform
* Receive general behavioral text message nudges
* Receive a free Fitbit to keep
Participants in the high-touch arm will:
* Learn new ways to manage pain without medication
* Receive tailored access to the self-guided digital self-management platform
* Received individualized pain coaching and optional group coaching sessions
* Participate in a structured walking or meditation curriculum
* Receive a free Fitbit to keep
Are You a Good Fit for This Trial?
This trial is for adults with liver cirrhosis who also have ongoing pain. Participants should be able to use digital tools and follow a self-management program. People with other serious health issues or those unable to participate in the activities may not be eligible.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- High-touch self-management program
- Low-touch self-management program
Trial Overview
The study compares two drug-free pain management programs: one offers basic digital support (low-touch), while the other provides more personalized coaching and group sessions (high-touch). Both groups learn new ways to manage pain, and all participants get a Fitbit.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants receive access to the self-guided digital self-management platform with automated educational content and behavioral nudges for 48 weeks.
Participants receive tailored digital self-management program, individualized pain coaching, and a structured walking or meditation curriculum selected through Active Choice as the primary behavioral focus for 48 weeks. The high-touch arm also includes on-demand coaching for low-pain self-efficacy and optional group coaching sessions.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor
Patient-Centered Outcomes Research Institute
Collaborator
University of Michigan
Collaborator
University of Miami
Collaborator
Johns Hopkins University
Collaborator
Mayo Clinic
Collaborator
Columbia University
Collaborator
University of California, San Francisco
Collaborator
Vanderbilt University Medical Center
Collaborator
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