40 Participants NeededMy employer runs this trial

Light Therapy for Fibromyalgia

(Light Bulb Trial)

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Overseen ByMatthew Mauck, MD, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of North Carolina, Chapel Hill
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether different types of light exposure can reduce pain for individuals with fibromyalgia, a condition causing widespread pain and fatigue. Participants will try two types of light treatments—Equal-Energy White Light and S-Cone Stimulating Chromatic Light—each for one week, to assess their effects on pain and sensitivity. This trial suits those who have experienced fibromyalgia or ongoing pain in multiple body areas for at least three months. Participants must be willing to use special light bulbs in their homes for two hours daily. As an unphased trial, this study offers a unique opportunity to explore innovative treatments and contribute to advancing fibromyalgia research.

What prior data suggests that this light therapy is safe for fibromyalgia?

Research has shown that both types of light therapy being tested—equal-energy white light and S-cone stimulating chromatic light—are generally safe.

For equal-energy white light, studies have found that low-level light therapy (LLLT) is well tolerated and has no known side effects when used correctly. However, it is not recommended for pregnant women.

Regarding S-cone stimulating chromatic light, past studies, especially those involving green light exposure (similar to S-cone stimulation), reported no safety concerns. This suggests that the treatment is safe for regular use.

Overall, both treatments in this trial have demonstrated good safety records in previous studies, with no reported adverse effects.12345

Why are researchers excited about this trial?

Researchers are excited about using light therapy for fibromyalgia because it offers a non-invasive alternative to standard treatments like medications and physical therapy. Unlike traditional methods, which often involve drugs targeting pain or inflammation, this approach utilizes specific types of light—equal-energy white light and S-cone stimulating chromatic light—to potentially influence sensory processing and pain perception. This innovative method could provide relief without the side effects associated with medications, and it works quickly, potentially showing results in just a week of daily 2-hour sessions.

What evidence suggests that this trial's treatments could be effective for fibromyalgia?

This trial will compare two types of light therapy for fibromyalgia: Equal-Energy White Light and S-Cone Stimulating Chromatic Light. Research has shown that light therapy can reduce pain in people with fibromyalgia. One study found that bright light treatments improved pain sensitivity and overall functioning. Another study demonstrated that whole-body light therapy reduced pain and enhanced quality of life. Specifically, colored light might improve pain and sleep quality. This therapy may work by influencing nerve cell function and inflammation management in the body. These findings offer hope that various light exposures can help manage fibromyalgia symptoms.678910

Who Is on the Research Team?

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Matt Mauck, MD, PhD

Principal Investigator

UNC Chapel Hill School of Medicine

Are You a Good Fit for This Trial?

This trial is for adults who have fibromyalgia or ongoing widespread muscle and joint pain with fatigue. Participants should be able to complete daily surveys and attend study visits over about a month.

Inclusion Criteria

Score of ≥7 on the Widespread pain index (WPI) and ≥5 on the symptom severity scale (SSS), or 4-6 on the WPI and ≥9 on the SSS in the 2016 Fibromyalgia Questionnaire
Willingness to adjust light levels in home environment so illumination from study light bulbs is twice ambient room illumination
Willingness to use study lightbulbs for 2 consecutive hours a day for 7 consecutive days for both conditions (total 14 days)
See 7 more

Exclusion Criteria

Pregnancy
History of photosensitivity or sensitivity to scintillating (mildly flickering) light
I expect my pain treatment plan to change in the next 3 months.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week

Treatment Period 1

Participants receive either S-cone stimulating chromatic light or equal-energy white light for 2 hours daily over a 7-day period

1 week
Daily light exposure sessions

Washout

A 1-week washout period with no light intervention, but continued daily symptom surveys

1 week

Treatment Period 2

Participants cross over to the alternate light condition for 2 hours daily over a 7-day period

1 week
Daily light exposure sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment, with continued daily symptom monitoring

1 week
Final study visit for follow-up questionnaires and optional testing

What Are the Treatments Tested in This Trial?

Interventions

  • Equal-Energy White Light
  • S-Cone Stimulating Chromatic Light

Trial Overview

The study tests whether exposure to colored light (S-cone stimulating chromatic light) versus regular white light, each given for 2 hours daily over a week, can help reduce pain in people with chronic pain conditions. Each participant tries both types of light during the study.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: S-cone stimulating chromatic light first followed by equal-energy white lightExperimental Treatment2 Interventions
Group II: Equal-energy white light first followed by S-cone stimulating chromatic lightExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of North Carolina, Chapel Hill

Lead Sponsor

Trials
1,588
Recruited
4,364,000+

Citations

What a 6-Week Clinical Trial Found About Whole-Body ...

This small feasibility study found encouraging improvements in pain, fatigue, sleep, quality of life, and other fibromyalgia-related outcomes ...

FibroLux is the first FDA-cleared therapeutic laser ...

In a clinical trial the FibroLux reduced tender points by 52%, and decreased pain by 53%. The secondary outcomes were changes in fatigue, ...

Evolution of the Quality of Life of Long-Term Fibromyalgia ...

There was a reduction in the Fibromyalgia Impact Questionnaire (FIQ) scores, with an average reduction of 27% after the first three months (M3) ...

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pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/27473633/

Morning Versus Evening Bright Light Treatment at Home to ...

However, only the morning light treatment led to a clinically meaningful improvement in function (>14% reduction from baseline FIQ) and morning ...

Light therapy for chronic pain: From molecular mechanisms ...

These approaches reduce pain through inhibition of glial cell activation, reduction of pro-inflammatory cytokine levels, and modulation of neuronal activity.

Light Therapy for Fibromyalgia

When used properly, there are no known side effects associated with low-level light therapy (LLLT). , LLLT should not be used by pregnant women.

Effects of Blue-enriched White Light Therapy on Sleep ...

This randomized controlled study aims to examine the effects of light therapy on sleep quality, depressive symptoms, psychomotor vigilance ...

What a 6-Week Clinical Trial Found About Whole-Body ...

The researchers reported that the intervention was well tolerated in this small study and that the treatment protocol was feasible and ...

Reduction of pain thresholds in fibromyalgia after very low ...

No adverse side effects were reported in any of the patients. CONCLUSIONS: Very low-intensity magnetic stimulation may represent a safe and effective treatment ...

Evaluation of Sound Therapy in a Population of Women ...

The main objective of the study is to assess with a Visual Analogue Scale of pain if 3 relaxation sessions with sound therapy delivered by tuning forks can ...