28 Participants NeededMy employer runs this trial

Exercise for Coronary Artery Dissection and Fibromuscular Dysplasia

AR
Overseen ByArmia R. Habil, MD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how varying levels of aerobic and resistance exercises affect individuals with Spontaneous Coronary Artery Dissection (SCAD) and Fibromuscular Dysplasia (FMD). The researchers aim to understand the impact of these exercises on heart and lung function, blood flow, and symptoms in those with these conditions. Participants will undergo three exercise tests to assess bodily responses. Ideal candidates for this study are those who experienced SCAD or FMD at least two months ago, are no longer experiencing chest pain, and can exercise without restrictions. As an unphased trial, this study offers a unique opportunity to contribute to understanding the effects of exercise on SCAD and FMD.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

What prior data suggests that these exercises are safe for people with SCAD and/or FMD?

Research has shown that aerobic and resistance exercises can be safe and beneficial for many people, including those with certain heart conditions. For example, one study found that patients exercised more effectively during cardiac rehab sessions without major issues. This finding suggests that, with careful monitoring, exercise might be safe for some individuals with heart problems.

However, not all exercises suit everyone. For instance, people with certain artery issues often avoid resistance exercises like push-ups and sit-ups, as these can strain the heart and blood vessels.

In general, while exercise is usually safe and helpful, following advice from healthcare professionals is crucial. They can create exercise plans that are safe and tailored to individual needs.12345

Why are researchers excited about this trial?

Researchers are excited about using aerobic and resistance exercises for treating Spontaneous Coronary Artery Dissection (SCAD) and Fibromuscular Dysplasia (FMD) because this approach focuses on non-invasive, lifestyle-based interventions. Unlike conventional treatments that may involve medications or surgical procedures, exercise offers a natural, holistic way to strengthen the cardiovascular system and improve overall health. This method aims to empower patients to manage their conditions through regular physical activity, potentially reducing the risk of future complications without the need for drugs or surgery.

What evidence suggests that aerobic and resistance exercises might be effective for SCAD and FMD?

Studies have shown that aerobic and resistance exercises can benefit people with Spontaneous Coronary Artery Dissection (SCAD) and Fibromuscular Dysplasia (FMD). In this trial, participants will engage in these exercises to assess their impact on these conditions. Research indicates that patients in cardiac rehabilitation, which includes these exercises, usually improve their exercise capacity. For example, one study found that all patients increased their aerobic capacity during rehab sessions. This suggests that moderate aerobic exercise is both safe and beneficial. Experts recommend this type of exercise for SCAD patients, as it aids in recovery and improves overall heart health.12346

Who Is on the Research Team?

EH

Elizabeth H. Dineen, DO

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for people who have had Spontaneous Coronary Artery Dissection (SCAD) or Fibromuscular Dysplasia (FMD), are at least 2 months past their event, currently free from chest pain, and able to exercise. It excludes those who are pregnant, medically unstable, severely obese, or unable to safely participate in exercise.

Inclusion Criteria

Able to provide written informed consent
I had SCAD or FMD over 2 months ago and have no chest pain now.

Exclusion Criteria

Pregnancy
Individuals who are deemed medically unstable
Participants who are unable to comply with study requirements
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Exercise Testing

Participants undergo three exercise tests to assess cardiopulmonary, hemodynamic, and symptom responses

1 week
3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after exercise testing

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Aerobic and resistance exercises

Trial Overview

The study tests how different levels of aerobic and resistance exercises affect heart and lung function and symptoms in people with SCAD or FMD. Participants will perform supervised exercise sessions while researchers monitor their responses.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Aerobic and resistance exerciseExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Citations

NCT07526766 | A Study Of Exercise In Patients With ...

The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and ...

Safety and Outcomes of Cardiac Rehabilitation for Patients ...

All 10 patients showed improvement in their aerobic exercise capacity during CR sessions, irrespective of their baseline functional capacity, with increase in ...

A Study Of Exercise In Patients With Spontaneous ...

The purpose of this study is to assess the cardiopulmonary, hemodynamic, and symptom responses to acute bouts of varying intensity aerobic and resistance ...

Physical activity and exercise in patients with spontaneous ...

Another study of 950 SCAD patients found that only 40% of SCAD patients were achieving current exercise recommendations prior to SCAD, even ...

Safety and Outcomes of cardiac rehabilitation for patients ...

All 10 patients showed improvement in their aerobic exercise capacity during CR sessions, irrespective of their baseline functional capacity, ...

Spontaneous Coronary Artery Dissection in Highly Active ...

Exercise-related SCAD was much more common in HAIs, present in 44.5% vs 28.2% of non-HAIs (P < 0.001). Among HAIs, 2.9% experienced an out-of-hospital cardiac ...