100 Participants Needed

Left Lateral Positioning for Fetal Growth Restriction

Recruiting at 1 trial location
RS
HE
Overseen ByHannah E Vincent, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether lying on the left side during pregnancy (left lateral recumbent positioning) can improve the growth of babies who aren't growing as expected. Researchers aim to determine if this position also affects the mother's overall health, stress levels, and the baby's heart function. Participants will either rest on their left side or receive regular care, with their physical activity tracked by a smartwatch. Pregnant individuals informed that their baby is smaller than expected and who are between 24 to 34 weeks pregnant might be suitable for this study. As an unphased study, this trial offers participants the opportunity to contribute to valuable research that could enhance pregnancy outcomes.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications. However, if you are on anticoagulation therapy, you cannot participate in the trial.

What prior data suggests that left-lateral positioning is safe for pregnant individuals?

Research shows that lying on the left side is generally safe and comfortable for pregnant women. Studies have found that this position can improve blood flow to the placenta and increase oxygen delivery to the baby, potentially aiding the baby's growth.

No reports indicate negative effects from lying on the left side during pregnancy. In fact, this position might reduce risks associated with other positions, such as lying on the back, which can lower blood flow. Prospective participants in a study on this topic can feel confident that lying on the side is considered safe and might even benefit the baby's growth.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores a simple and non-invasive method to potentially improve fetal growth in cases of fetal growth restriction. Unlike traditional medical interventions that might involve medication or more intensive monitoring, this approach simply involves pregnant individuals spending time in a left lateral recumbent position. This positioning may enhance blood flow to the placenta, potentially benefiting fetal development. Additionally, the trial's use of smartwatches to track participants' activity levels adds a modern twist, allowing for precise monitoring and personalized insights.

What evidence suggests that left-lateral positioning is effective for fetal growth restriction?

Research has shown that lying on the left side during pregnancy can improve blood flow to the uterus and placenta, aiding in oxygen delivery to the baby. One study found that blood flow decreased by 23% when mothers lay on their backs instead of their sides. Another study observed that resting on the left side increased fetal movements, often a sign of better health for the baby. Additionally, this position has been linked to more fetal urine production, indicating better fluid balance for the baby. In this trial, participants in the intervention group will practice left-lateral recumbent positioning to assess its potential benefits for fetal growth and health, especially in pregnancies where growth is a concern.12467

Who Is on the Research Team?

MP

Manesha Putra, MD

Principal Investigator

University of Colorado Anschutz, Department of Obstetrics and Gynecology

Are You a Good Fit for This Trial?

This trial is for pregnant individuals between 24 and 34 weeks' gestation diagnosed with fetal growth restriction. They must be fluent in English or Spanish. The study excludes those not meeting these criteria.

Inclusion Criteria

I am pregnant with one baby and between 24 to 34 weeks along.
I am fluent in either English or Spanish.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants practice left-lateral position daily for 4 hours with stretching, or receive standard care

4 weeks
1 visit (in-person) after 4 weeks

Follow-up

Participants are monitored for maternal metabolomics, delivery outcomes, and fetal cardiac function

4 weeks
1 visit (in-person) at delivery

What Are the Treatments Tested in This Trial?

Interventions

  • Left lateral recumbent positioning
Trial Overview The trial tests if lying on the left side can help babies grow when there's fetal growth restriction. It compares daily left-lateral positioning with standard care, looking at baby's growth, mother's metabolism and mental health, baby's heart function, and delivery outcomes.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Intervention group AExperimental Treatment1 Intervention
Group II: Intervention group BActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1,842
Recruited
3,028,000+

Citations

Maternal Left Lateral Position in Fetal Growth RestrictionThe goal of this clinical trial is to learn if maternal left-lateral positioning in pregnancy works to treat fetal growth restriction.
Maternal rest improves growth in small-for-gestational-age ...Observational studies have indicated that maternal rest in the left lateral position improves maternal cardiac output and uterine blood flow.
The effect of maternal position on placental blood flow and ...With maternal supine positioning, there is a 23% reduction in maternal-placental blood flow and a further 14% reduction in fetal oxygen delivery ...
(PDF) Effect of Left lateral position on Intrauterine Fetal ...Conclusion: Maternal rest in left lateral position improved fetal movements. Recommendations: Pregnant women complaining from decreased fetal ...
Impact of maternal posture on fetal physiology in human ...Amniotic fluid​​ In the third trimester, 1 hour of maternal rest in the left lateral posture has been found to significantly increase the fetal urine production ...
Maternal Left Lateral Position in Fetal Growth RestrictionThe goal of this clinical trial is to learn if maternal left-lateral positioning in pregnancy works to treat fetal growth restriction.
Maternal Rest Improves Fetal Growth in Small-For- ...The EFW was measured 2 weeks following maternal rest. Results Of the 265 fetuses, FGR was identified in 56% (148/265) and SGA in 44% (117/265). Following ...
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