Yogurt Smoothies for Brain and Gut Health

(SPARK Trial)

KL
AL
Overseen ByAlaina L Pearce, Ph.D.
Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: Penn State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether daily yogurt consumption can improve brain and gut health in children. Researchers will examine yogurt's effects on thinking skills like memory and focus, brain activity, and gut bacteria. Children will consume either one or two yogurt smoothies daily or a fruit juice as a control for four weeks. The trial seeks children aged 7-9 from Central Pennsylvania who are healthy, enjoy yogurt, and are not on medications affecting appetite or cognitive function. Results will help determine if yogurt supports healthy brain and gut development in children. As an unphased trial, this study offers a unique opportunity to contribute to the scientific understanding of yogurt's potential benefits for children's health.

Will I have to stop taking my current medications?

If your child is taking medications that affect appetite or cognitive function, they will need to stop taking them to participate in the trial.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that yogurt is generally safe for children. In one study involving children aged 12 to 48 months, consuming a yogurt drink daily did not cause any major side effects, indicating that yogurt is safe for daily consumption. Yogurt is rich in important nutrients such as calcium and protein and often contains probiotics. Probiotics are beneficial bacteria that help maintain a healthy stomach. While further research is needed to explore additional benefits, current evidence supports yogurt as a safe food choice for kids.12345

Why are researchers excited about this trial?

Researchers are excited about yogurt smoothies for brain and gut health because they offer a natural, food-based approach to enhancing well-being, which is quite different from traditional supplements or medications. Unlike standard options that might include probiotics in pill form, these smoothies combine beneficial bacteria with nutrients in a delicious, easy-to-consume format. This could make them a more appealing choice, especially for children, as they can be integrated seamlessly into everyday diets. Additionally, the dual focus on both brain and gut health suggests a holistic approach, potentially offering benefits that go beyond what individual probiotic supplements can achieve.

What evidence suggests that yogurt smoothies might be an effective treatment for brain and gut health?

Research has shown that yogurt may benefit brain health, including memory and focus. New findings suggest that probiotics, the beneficial bacteria in yogurt, can enhance cognitive function. One study indicated that certain probiotics in yogurt might alter brain responses, potentially boosting cognitive skills. Additionally, animal studies have found that probiotics in yogurt can reduce signs of depression in mice, suggesting mental health benefits. Overall, these findings suggest that yogurt could support both brain and gut health.

In this trial, participants will receive either one or two daily yogurt smoothies or a daily fruit juice control to evaluate the effects on brain and gut health.12678

Who Is on the Research Team?

KL

Kathleen L Keller, Ph.D.

Principal Investigator

Penn State University

Are You a Good Fit for This Trial?

This trial is for children aged 7 to 9 living in Central Pennsylvania. Participants should be generally healthy and not currently consuming yogurt regularly. The study aims to include kids who can follow the smoothie regimen and are willing to undergo brain scans, computer tasks, surveys, and provide stool samples.

Inclusion Criteria

My child is willing to drink and likes the fermented dairy smoothie.
My child is healthy and does not have any metabolic, gastrointestinal, or developmental disorders.
My child is not on medication that affects their appetite or thinking.
See 2 more

Exclusion Criteria

They do not speak English fluently
They are not from families of rural communities (assessed by National Center for Education Statistics local classifications)
Their parent is unable to attend the study visits
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Children consume either yogurt smoothies or fruit juice daily for 4 weeks, with cognitive and gut health assessments

4 weeks
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Yogurt Smoothie
Trial Overview The study tests if daily consumption of yogurt smoothies affects brain function and gut health in children. It compares cognitive skills, brain activity, and microbiome changes between groups drinking fruit juice or one/two yogurt smoothies a day over four weeks.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Active Control
Group I: 2 daily yogurt smoothiesExperimental Treatment1 Intervention
Group II: 1 daily yogurt smoothieExperimental Treatment1 Intervention
Group III: daily fruit juice controlActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Penn State University

Lead Sponsor

Trials
380
Recruited
131,000+

National Dairy Council

Collaborator

Trials
20
Recruited
1,800+

Citations

Yogurt Smoothies for Brain and Gut Health (SPARK Trial)It compares cognitive skills, brain activity, and microbiome changes between groups drinking fruit juice or one/two yogurt smoothies a day over ...
Child Yogurt Intervention for Cognitive and Brain HealthSmoothie Program for Achieving and Resilient Kids (SPARK Study): Prior literature suggests that yogurt may be beneficial for brain health, including cognitive ...
Cognitive Function and the Consumption of Probiotic FoodsEmerging evidence that probiotics, such as those in yogurt and other dairy products, can have a positive impact on cognitive function.
Probiotic found in yogurt can reverse depression symptomsResearchers have reversed depression symptoms in mice by feeding them Lactobacillus, a probiotic bacteria found in live-cultures yogurt.
Changing gut bacteria through diet affects brain function, ..."Our findings indicate that some of the contents of yogurt may actually change the way our brain responds to the environment," said UCLA's ...
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of ...In this review, we summarize the current state of the literature triangulating diet, microbiota, and host behavior/brain processes and discuss potential ...
How yogurt supports healthy digestionYogurt is high in calcium, protein, selenium, B-12 and other nutrients. Many yogurts also contain probiotics — the beneficial bacteria that live ...
Randomized, Double-Blind, Placebo-Controlled Study of ...To assess the effects of daily consumption of a synbiotic yogurt drink on the health, growth, and quality of life of healthy children 12-48 months of age in out ...
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