TES-TI for Epilepsy

(SLEEP-TIES Trial)

This trial tests a new method called TES-TI, which uses electrical stimulation to enhance deep sleep, reduce seizures, and support emotional health in people with epilepsy. Participants will be divided into two groups: one will receive real stimulation first, followed by a placebo version, while the other group will experience the reverse order. Individuals with epilepsy and frequent seizures that do not respond well to treatment may be suitable candidates. Participants must speak English, be a citizen or permanent resident, and not have other neurological disorders or certain medical devices.

As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could improve epilepsy treatment.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Previous studies have shown that transcranial electrical stimulation with temporal interference (TES-TI) is safe and well-tolerated. Research indicates that this method does not cause significant harm to the brain or nervous system. Specifically, one study found that TES-TI is safe for both brain and mental functions.

TES-TI is unique because it uses a non-invasive method called transcranial electrical stimulation to potentially manage epilepsy. Unlike traditional options like anti-seizure medications, which can have systemic side effects, TES-TI directly targets brain activity by delivering mild electrical currents to the scalp, potentially offering a safer alternative with fewer side effects. Researchers are excited about TES-TI because it offers a novel approach to altering brain function without the need for surgery or medication, and it could provide a new avenue for treatment, especially for those who do not respond well to current therapies.

Research has shown that Transcranial Electrical Stimulation with Temporal Interference (TES-TI) might help reduce epilepsy symptoms. Studies have found that TES-TI can significantly lower abnormal brain activities between seizures. This suggests that TES-TI might reduce seizure frequency or severity. Additionally, research indicates that TES-TI can reach deep brain areas without surgery, potentially easing epilepsy symptoms. Although more research is needed, these early findings are promising and suggest that TES-TI could benefit people with epilepsy. Participants in this trial will experience both real and sham stimulation to evaluate TES-TI's effectiveness.¹⁴⁶⁷⁸