Mannitol Solution for Small Bowel Sensation
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this research is to identify the concentration of mannitol solution (a type of sugar alcohol) that will generate a range of symptoms in individuals without Disorders of Gut Brain Interaction (DGBI) to establish the normative range of responses to small bowel (SB) distension.
Who Is on the Research Team?
Xiao Jing Wang, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for healthy adults without functional gastrointestinal disorders or gut-brain interaction problems. Participants should not have any digestive diseases or symptoms and must be able to safely drink mannitol solutions.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
Researchers are testing different strengths of a sugar alcohol solution (mannitol) given by mouth to see how it affects the small intestine, using scans to measure responses. The goal is to find normal reactions in people without gut issues.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Healthy adult volunteers will receive all three mannitol solution osmolarities-76 milliosmol (mOsm/L), 189 mOsm/L, and 325 mOsm/L-on three separate testing occasions spaced at least 5 days apart. Each solution will be administered orally as 500 mL radiolabeled with Pentetate Indium Disodium In-111 (111Indium-DTPA).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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