ACT + Ketamine for Depression

(K-ACT Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of British Columbia
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Ketamine is often used to treat depression where standard treatments have failed. Yet, even with ketamine, depression can persist and make it difficult to keep up with life. This study examines whether it is practical, safe and helpful to use a talk therapy (Acceptance and Commitment Therapy, ACT) in patients with difficult-to-treat depression receiving ketamine through the Ketamine Intervention Program at UBC Hospital. Researchers expect that combining ACT plus Ketamine ("K-ACT") will be feasible, safe, and will help patients functioning better in their daily lives, feeling that they are recovering, and having fewer symptoms of depression.

Are You a Good Fit for This Trial?

This trial is for adults with depression that hasn't improved after standard treatments, who are receiving ketamine at UBC Hospital. Participants should be able to take part in talk therapy sessions.

Inclusion Criteria

Have a referral from a community psychiatrist who agrees to follow the patient throughout the entire trial
I am 18 years old or older.
Have the ability to provide informed consent
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Exclusion Criteria

Allergy to ketamine
History of ketamine use disorder
History of alcohol or other substance use disorder in the past 6 months
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What Are the Treatments Tested in This Trial?

Interventions

  • K-ACT Intervention

Trial Overview

The study tests whether combining Acceptance and Commitment Therapy (a type of talk therapy) with ketamine treatment helps people with hard-to-treat depression feel better and function more effectively.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: K-ACT InterventionExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of British Columbia

Lead Sponsor

Trials
1,506
Recruited
2,528,000+