Endoform + Symphony for Diabetic Foot Ulcers

This trial tests the safety and effectiveness of a combination of treatments—Endoform™ Natural, Endoform™ Antimicrobial, and Symphony™—for diabetic foot ulcers that do not heal on their own. The goal is to assess how well these treatments improve ulcers after 12 weeks. The trial seeks individuals with a diabetic foot ulcer lasting more than four weeks but less than a year, specifically those with a Wagner Grade 1 or 2 ulcer. Participants must attend weekly visits and have an ulcer that is neither infected nor caused by a condition other than diabetes.

As an unphased trial, this study provides a unique opportunity to contribute to understanding how these treatments can benefit patients with diabetic foot ulcers.

The trial does not specify if you need to stop taking your current medications. However, if you are on immune-suppressants, systemic corticosteroids over 10mg daily, cytotoxic chemotherapy, or topical steroids on the ulcer, you may not be eligible to participate.

Research has shown that treatments using Endoform™ and Symphony™ are generally well-tolerated. One study involving a similar treatment (a dissolvable glass microfiber material) for diabetic foot ulcers found no negative effects linked to the treatment. This suggests that Endoform™ Natural, Endoform™ Antimicrobial, and Symphony™ are likely safe for most people. Additionally, Endoform™ has been shown to help wounds heal faster than some other treatments. While this is encouraging, consider personal health conditions and consult a healthcare provider before deciding to join a trial.¹²³⁴⁵

Unlike the standard care for diabetic foot ulcers, which often involves topical treatments, wound dressings, and debridement, the combination of Endoform™ Antibacterial, Endoform™ Natural, and Symphony™ stands out because of its unique blend of advanced wound care technologies. Endoform™ products are derived from ovine forestomach and are known for their natural extracellular matrix, which supports tissue regeneration. Symphony™ is a novel addition that enhances the wound healing process by providing a conducive environment for skin cell growth. This combination not only targets bacterial infection but also actively promotes tissue repair, offering a promising new approach to managing diabetic foot ulcers.

Research has shown that using Endoform™ and Symphony™ together can effectively treat diabetic foot ulcers. One study found that ulcers treated with Endoform healed up to 5.6 weeks faster, increasing recovery chances. Another study demonstrated a significant decrease in wound size and depth, indicating improved wound care. In this trial, participants with Wagner Grade 1 or 2 diabetic foot ulcers will receive treatment with Endoform™ Natural, Endoform™ Antibacterial, and Symphony™ to enhance healing for chronic diabetic foot ulcers.¹²³⁶⁷