20 Participants NeededMy employer runs this trial

Blood Flow Restriction Training for Type 2 Diabetes

JP
Overseen ByJonathan P Little, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of British Columbia
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how blood flow restriction training, a special exercise technique, affects the immune system and energy use in people with type 2 diabetes. Participants will walk on a treadmill with or without this technique for six weeks. The researchers aim to determine if this exercise can improve health outcomes for those with type 2 diabetes. It suits adults with type 2 diabetes who exercise less than 150 minutes per week and have no conditions that make exercise unsafe. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance exercise recommendations for type 2 diabetes.

What prior data suggests that blood flow restriction training is safe for adults with type 2 diabetes?

Research has shown that blood flow restriction training (BFRT) is generally safe for people with type 2 diabetes. Studies have found that BFRT improves the body's ability to handle sugar, with no serious side effects reported. In one study, blood pressure increased during exercise but remained within safe levels. Another study demonstrated that after three months of BFRT, participants showed no signs of muscle damage or other serious issues. Some participants even reported less muscle pain compared to other exercises. Overall, these findings suggest BFRT is safe and well-tolerated for most people.12345

Why are researchers excited about this trial?

Researchers are excited about blood flow restriction training for type 2 diabetes because it offers a novel approach to exercise that might enhance blood sugar control. Unlike standard treatments like medication or diet changes, this method involves treadmill walking while restricting blood flow to certain muscles. This technique may amplify the benefits of exercise by promoting muscle growth and improving insulin sensitivity in a shorter time frame. By potentially making workouts more effective, it could provide a new, non-drug option for managing diabetes.

What evidence suggests that blood flow restriction training is effective for type 2 diabetes?

This trial will compare treadmill walking with blood flow restriction to treadmill walking without restriction for individuals with type 2 diabetes. Research has shown that blood flow restriction training (BFRT) can benefit people with type 2 diabetes. Studies have found that combining BFRT with exercise helps the body use sugar more efficiently. One study showed that BFRT can increase muscle size and strength, similar to traditional heavy weightlifting. It also helps reduce harmful belly fat and boosts metabolism. Additionally, BFRT may improve overall fitness, as evidenced by longer walking distances in other conditions. These findings suggest that BFRT could be a promising way to manage type 2 diabetes.16789

Are You a Good Fit for This Trial?

This trial is for adults with type 2 diabetes. Participants should be generally healthy enough to exercise and not have any conditions that would make exercise unsafe.

Inclusion Criteria

Completing less than 150 minutes of moderate-vigorous physical activity per week
I have type 2 diabetes and my HbA1c is between 5.7% and 9.0%.
I am between 19 and 64 years old.

Exclusion Criteria

I have a condition that affects my red blood cells, like sickle cell anemia.
My type 2 diabetes medication has changed in the last 3 months.
I have a chronic muscle or bone problem, or recent heart issue that stops me from exercising.
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants are randomized to either treadmill walking or treadmill walking with blood flow restriction for 6 weeks, 3 days per week.

6 weeks
18 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Blood Flow Restriction Training

Trial Overview

The study tests whether doing blood flow restriction training (a special kind of exercise where blood flow to muscles is partially limited) for six weeks affects immune cell function and energy use in people with type 2 diabetes. Participants are randomly assigned to groups.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Treadmill walking with blood flow restrictionExperimental Treatment2 Interventions
Group II: Treadmill WalkingActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of British Columbia

Lead Sponsor

Trials
1,506
Recruited
2,528,000+

Citations

The Effect of Blood Flow Restriction Training on Glycemic ...

Blood flow restriction training (BFRT) combined with resistance or aerobic exercise has been shown to improve the glucose uptake in humans.

Effects of blood flow restriction training on muscle fitness and ...

BFR combined with low-intensity RT training effectively improved body composition index, increased muscle mass, improved neuromuscular ...

Blood Flow Restriction (BFR) and Possible Applications in ...

The study found when comparing BFR with traditional high-load resistance training, "BFRT induces similar gains in muscle mass and strength. BFRT ...

Blood Flow Restriction Training in Chronic Heart Failure ...

The secondary outcomes of this study are to determine if such a training intervention leads to clinical improvements in exercise intolerance symptoms and ...

The Systemic Effects of Blood Flow Restriction Training

BFR was found to improve 6-minute walk test distances 17% (compared to 1.5% improvement in exercising control) in patients with ESRD on ...

Effects of Blood Flow Restriction Exercise and Possible ...

Recent research indicates that BFRT has beneficial effects on glucose and mitochondrial metabolism. BFRT may therefore qualify as a valuable exercise ...

Blood Flow Restriction (BFR) and Possible Applications in ...

This review covers the effects of BFRT in healthy populations and in persons with impaired physical fitness, the mechanisms of action of this ...

8.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/39093729/

Acute effects of blood flow restricted aerobic exercise in ...

The higher blood pressure observed during the BFR exercise remained within safe limits. These results suggest that people with T2DM can safely ...

Effect of Resisted Blood Flow Restriction (BFR-DM2)

The goal of this clinical trial is to investigate the effect of adding resisted blood flow restriction (BFR) training to a standard exercise ...