50 Participants NeededMy employer runs this trial

Continuous Glucose Monitoring for Gestational Diabetes

(POSTPOD Trial)

RS
DL
Overseen ByDana Levin-Lopez, MPH
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: University of California, Los Angeles
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how using a continuous glucose monitor (CGM) immediately after childbirth can help predict the risk of developing Type 2 Diabetes in those who had gestational diabetes. Participants will wear the CGM device for 24 hours to track blood sugar levels. Individuals who received prenatal care at UCLA Health, plan to deliver at a UCLA hospital, and were diagnosed with gestational diabetes may qualify for this study. Participants will also complete surveys about their experiences months after delivery. As an unphased study, this trial offers a unique opportunity to contribute to groundbreaking research that could enhance future diabetes care.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using metformin, steroids, or terbutaline within 4 hours of delivery.

What prior data suggests that this continuous glucose monitoring is safe for postpartum patients?

Research has shown that continuous glucose monitors (CGMs) are safe for pregnant women with diabetes. One study found that the Dexcom G7 CGM system was accurate and easy to use, providing reliable blood sugar readings without requiring extra blood tests. This allows real-time monitoring of blood sugar levels without frequent finger pricks.

Another study suggested that CGMs are particularly beneficial for women with gestational diabetes, a type of diabetes that can occur during pregnancy, especially if they experience frequent changes in blood sugar levels. This is crucial for effective blood sugar management by both patients and doctors.

Overall, using CGMs during pregnancy has demonstrated positive safety results, making them a trusted tool for monitoring blood sugar levels.12345

Why are researchers excited about this trial?

Unlike traditional methods for managing gestational diabetes, which typically involve frequent finger-prick blood tests, the continuous glucose monitor (CGM) offers real-time tracking of blood sugar levels. This device provides a much clearer picture of glucose fluctuations over a 24-hour period without the need for constant manual testing. Researchers are excited about this approach because it could lead to more precise management of blood sugar levels, potentially improving outcomes for both mothers and their babies. Plus, the convenience and reduced discomfort of using a CGM could make managing gestational diabetes less burdensome.

What evidence suggests that continuous glucose monitoring is effective for predicting long-term risk of Type 2 Diabetes in gestational diabetes patients?

Research has shown that continuous glucose monitoring (CGM) can help people with gestational diabetes control their blood sugar levels more effectively. In one study, 65 pregnant women with Type 2 diabetes and gestational diabetes used CGM and managed their glucose levels more effectively. Another study with 340 women demonstrated that CGM led to more stable blood sugar levels and better overall control. Additionally, using CGM in gestational diabetes has been linked to healthier outcomes for both mothers and their babies, such as lower birth weights and fewer cases of large babies. In this trial, participants will receive a Continuous Glucose Monitor within 2 hours after delivery for 24-hour collection of glycemic data. These findings suggest that CGM could be a helpful tool for managing gestational diabetes and its long-term effects.12367

Who Is on the Research Team?

CH

Christina Han, MD

Principal Investigator

University of California, Los Angeles

Are You a Good Fit for This Trial?

This trial is for women aged 18 or older who received prenatal care and delivered at UCLA, and were diagnosed with gestational diabetes during pregnancy. Women can't join if they have certain health conditions, allergies to adhesives, are having twins or more, had major delivery complications, or used specific medications.

Inclusion Criteria

Maternal age >= 18 years
Prenatal care at UCLA Health
Planning to deliver at UCLA Ronald Reagan or UCLA Santa Monica
See 1 more

Exclusion Criteria

Known allergy to medical-grade adhesive
Multifetal gestation
Postpartum hemorrhage
See 10 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Immediate Postpartum Monitoring

Participants are provided a Continuous Glucose Monitor within 2 hours after delivery and wear the device for 24 hours

24 hours
1 visit (in-person)

Postpartum Survey Follow-up

Participants complete surveys regarding their experience at 1-3 months postpartum and 12-14 months postpartum

1-3 months and 12-14 months postpartum

Follow-up

Participants are monitored for safety and effectiveness after initial monitoring

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Continuous Glucose Monitor

Trial Overview

The study tests whether wearing a continuous glucose monitor (CGM) for 24 hours right after giving birth can help predict future risk of developing type 2 diabetes in women who had gestational diabetes. Participants also complete follow-up surveys months later.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Continuous Glucose MonitorExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, Los Angeles

Lead Sponsor

Trials
1,594
Recruited
10,430,000+

Citations

Continuous glucose monitoring in early gestational diabetes ...

Furthermore, Yu et al. reported that in a study with 340 women with GDM, CGM resulted in less glucose variability and better glycaemic control ...

Continuous glucose monitoring system in diabetes in pregnancy

A retrospective cohort study evaluating 65 pregnant women with T2D and GDM found that both isCGM and rtCGM improved glycemic control. However, ...

Real-Time Continuous Glucose Monitoring in Pregnancies ...

We hypothesize that pregnant people with GDM using real-time CGM can achieve higher percent glucose time in range (%TIR; 60–140 mg/dL) compared ...

Evidence for improved glucose metrics and perinatal ...

Evidence for improved glucose metrics and perinatal outcomes with continuous glucose monitoring compared to self-monitoring in diabetes during pregnancy.

Continuous glucose monitoring in gestational diabetes ...

These continuous glucose data can provide deeper insight into glycaemic patterns across pregnancy, optimal CGM wear duration, patient selection, and the ...

Continuous glucose monitoring metrics and pregnancy ... - PMC

Real-time continuous glucose monitoring (CGM) improves pregnancy outcomes in women with type 1 diabetes in pregnancy (5,6). who are recommended to attain ≥70% ...

Expert Perspectives on Evolving Evidence on CGM Use in ...

Continuous glucose monitoring (CGM) is a method of assessing and monitoring glucose levels that provide real-time data for glucose management.