"Do More, Feel Better" for Depression in Older People with HIV

SM
IG
Overseen ByIsabell Griffith Fillipo, BA
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Washington
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

More than half of people living with HIV (PWH) in the United States are 50 years of age or older. Older PWH have a 2.3-fold increased risk of depression compared to their peers without HIV. The investigator team has developed a streamlined lay-delivered behavioral activation intervention called "Do More, Feel Better" that has been shown to decrease depressive symptoms among older adults obtaining services in community senior centers. The investigators propose to (1) identify barriers and facilitators to improving mental health among older PWH by using this intervention in the context of Ryan White case management services, (2) adapt and enhance the intervention to meet the needs of older PWH, and (3) conduct a pilot randomized controlled trial to determine the acceptability, feasibility, and appropriateness of the adapted DMFB intervention.

Who Is on the Research Team?

SM

Susan M Graham, MD MPH PhD

Principal Investigator

University of Washington

Are You a Good Fit for This Trial?

This trial is for people aged 50 or older who are living with HIV and experiencing depression. Participants should be receiving case management services, such as those provided through the Ryan White program.

Inclusion Criteria

English-speaking
Resident in Washington for at least 1 year
I have significant symptoms of depression.
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Exclusion Criteria

Participants in Aim 1 and 2 work (interviews and theater testing)
Active suicidal ideation
Dementia or Telephone Interview for Cognitive Status-modified (TICS-M) score less than 21
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What Are the Treatments Tested in This Trial?

Interventions

  • "Do More, Feel Better" for Older People with HIV

Trial Overview

"Do More, Feel Better" is a talk-based program designed to help older adults with HIV manage depression by encouraging positive activities. The study will test if this adapted approach works well and fits into existing support services.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Adapted "Do More, Feel Better" InterventionExperimental Treatment1 Intervention
Group II: Usual careActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Washington

Lead Sponsor

Trials
1,858
Recruited
2,023,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+