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Online Cognitive Behavioural Therapy for Depression

(ACTION-MS onli Trial)

Not yet recruiting at 1 trial location
AT
LK
Overseen ByLitza Kiropoulos
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Melbourne
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Individuals with MS experience significantly high levels of depression which are higher than in any other chronic illness or neurological disorder. Depression can occur at any point in the course of the disease. Cognitive behavioural therapy (CBT) has been found to be effective in treating depression in people with MS. However, many individuals with MS who would benefit from CBT for depression do not participate in face-to-face treatment due to lack of clinician referral, accessibility, modality preference, cost, and mobility and travel issues due to health reasons.

Given the acceptability and preference for telehealth treatment options, digital-based psychological interventions can be another appealing treatment option as these programs have the ability to deliver interactive CBT treatments for depression to individuals with MS at a time and location convenient to the individual.

The current trial proposes to test the acceptability, effectiveness, satisfaction and cost-effectiveness of an 8-week online depression intervention targeting individuals with multiple sclerosis and compare this intervention with an 8-week online health and wellbeing in MS informational intervention.

Are You a Good Fit for This Trial?

This trial is for adults diagnosed with multiple sclerosis who are experiencing depression or anxiety. Participants should be able to use the internet and be interested in trying an online program to help manage their mood.

Inclusion Criteria

I have been diagnosed with multiple sclerosis.
Reports mild to moderate depressive symptoms, defined as a score of 14-28 on the Beck Depression Inventory-II (BDI-II)
I am 18 years old or older.

Exclusion Criteria

Severe depressive symptoms, defined as a BDI-II score of 29 or greater, as assessed using the BDI-II and SCID-5
Currently undertaking psychological treatment for depression and/or anxiety
A serious psychological disorder, including psychosis, bipolar disorder, or current substance use disorder, as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
See 3 more

What Are the Treatments Tested in This Trial?

Interventions

  • ACTION-MS website

Trial Overview

The study compares two 8-week online programs for people with MS: one offers cognitive behavioural therapy (CBT) tailored for depression, while the other provides general health and wellbeing information related to MS.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Behavioural Therapy (CBT) for depressionExperimental Treatment1 Intervention
Group II: Health and Wellbeing informational interventionActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Melbourne

Lead Sponsor

Trials
193
Recruited
1,287,000+

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