Denture Adhesives for Denture Retention

This trial tests three new denture adhesive creams to evaluate their effectiveness in keeping dentures in place for 13 hours. Participants will use one of the new adhesives, a standard product, or no adhesive at all. The goal is to determine which adhesive best secures dentures. Individuals with a full set of upper dentures and stable lower dentures or teeth may qualify for this trial. As an unphased trial, this study provides an opportunity to contribute to important research that could enhance denture adhesives for everyone.

The trial does not specify if you need to stop taking your current medications, but if you are taking a bisphosphonate drug, you cannot participate. Also, if your medication might interfere with the study, the investigator may decide you should not participate.

Research has shown that there isn't enough published data to clearly link denture adhesives, like those under testing, to injuries or side effects. However, many people find these products easy to use. For instance, one study found that 80% of users reported it was "very easy" or "extremely easy" to remove dentures with similar adhesives.

For the second adhesive under testing, some lab studies have shown that denture creams can harm certain cells in the mouth. However, these results come from lab tests, not real-life use. Safety instructions for these products advise avoiding contact with skin and eyes, which is common advice for many consumer products.

The third adhesive carries similar safety notes. Warnings exist about possible risks from excessive use, such as swallowing too much, which can cause issues like blockages. These concerns are typical for many denture creams and do not indicate a special risk with these new formulas.

Researchers are excited about these experimental denture adhesives because they could offer improved denture retention compared to current options like commercially available adhesives. Each of the three new adhesives is designed to provide a strong and lasting bond with just a single application, potentially offering more convenience and reliability for users. Unlike existing products, which might vary in consistency or hold time, these adhesives are being tested for their unique formula that could enhance comfort and confidence for denture wearers. If successful, these adhesives could significantly improve the daily experience for those using dentures.

This trial will compare the effectiveness of different denture adhesives. Research has shown that denture adhesives can prevent dentures from becoming loose. Participants may receive Experimental Denture Adhesive 1, which studies found reduces the frequency of denture slippage compared to using no adhesive. Another group will receive Experimental Denture Adhesive 2, which has been shown to keep dentures more secure and stable than using no adhesive. A third group will receive Experimental Denture Adhesive 3, which also improves denture stability and bite strength compared to using no adhesive. Overall, these adhesives help keep dentures in place better than not using any adhesive.⁶⁷⁸⁹¹⁰