Sedation Methods for Emergency Intubation
(INSPIRE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The INtubation with Sedation Only to Preserve Independent Respiratory Effort (INSPIRE) trial is a pragmatic, non-blinded, parallel-group, randomized clinical trial comparing the effect of intubation with sedation only (intervention group) versus intubation with sedation plus neuromuscular blockade (control group) among adults undergoing emergency tracheal intubation in the ED and ICU with regard to the outcomes of: (1) hypoxemia during intubation, (2) successful intubation on the first attempt, and (3) awake immobility and PTSD symptoms. Patients who are determined by treating clinicians to require emergency tracheal intubation and who meet eligibility criteria will be enrolled and randomly assigned to either intubation with sedation only or intubation with sedation plus neuromuscular blockade.
Who Is on the Research Team?
Stephanie C DeMasi, MD, MS
Principal Investigator
Vanderbilt University Medical Center
Jonathan D. Casey, MD, MSc
Principal Investigator
Vanderbilt University Medical Center
Matthew W. Semler, MD, MSc
Principal Investigator
Vanderbilt University Medical Center
Are You a Good Fit for This Trial?
This trial is for adults in the emergency department or ICU who need urgent breathing tube placement (intubation) due to severe breathing problems or metabolic acidosis. Patients are included if their doctors decide they require emergency intubation and meet other basic eligibility criteria.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Trial Overview
The study compares two ways of performing emergency intubation: one group gets only sedative medication, while the other receives both a sedative and a muscle-paralyzing drug. Participants are randomly assigned to either approach.
How Is the Trial Designed?
2
Treatment groups
Active Control
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University Medical Center
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.