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CoQ10 Products for CoQ10 Blood Levels

CA
SC
Overseen BySara Campbell, MPH
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Midwest Center for Metabolic and Cardiovascular Research
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests how well two different CoQ10 products absorb into the bloodstream. CoQ10, a nutrient that aids energy production in cells, is compared in a high-absorption version versus a standard one. Healthy men and women who can pause their dietary supplements might be suitable candidates. Participants will take each product, undergo blood tests, and eat standardized meals to ensure consistent results. This trial provides a chance to determine which product delivers CoQ10 more effectively. As an unphased trial, it offers participants the opportunity to contribute to understanding CoQ10 absorption, potentially benefiting future supplement development.

Do I have to stop taking my current medications for the trial?

You may need to stop taking certain medications or supplements that interfere with CoQ10 metabolism, like lipid-lowering, anti-hypertensive, hypoglycemic, anti-coagulant, and psychotherapeutic therapies, 14 days before the trial and during the study. However, if you're on a stable dose of other medications, you can continue as long as the dose hasn't changed in the last 3 months.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Studies have shown that Coenzyme Q10 (CoQ10) is generally safe for people. Research indicates that CoQ10 has low toxicity and doesn't cause serious side effects. CoQ10 is already available as a dietary supplement, and people can safely take up to 1200 mg per day, though most commonly, they use doses between 100 to 200 mg per day.

In this trial, both the high absorption CoQ10 and the standard CoQ10 are administered in 100 mg doses, which are well within the safe range. Past studies have not identified any major safety concerns at this level. Although the high absorption version is designed for better absorption, it is expected to be as safe as the standard version.

Overall, CoQ10 is well-tolerated by most people, making it a low-risk option for those considering joining the trial.12345

Why are researchers excited about this trial's treatments?

Researchers are excited about the high absorption CoQ10 product because it promises better absorption and bioavailability compared to standard CoQ10 supplements. Most CoQ10 treatments work to boost energy levels and support heart health, but they often struggle with poor absorption in the body. The high absorption formula is designed to overcome this barrier, potentially allowing more CoQ10 to enter the bloodstream, which could enhance its effectiveness. This could mean more efficient support for cellular energy production and antioxidant protection, making it a promising option for individuals seeking better CoQ10 supplementation.

What evidence suggests that this trial's treatments could be effective for CoQ10 blood levels?

Studies have shown that CoQ10 supplements effectively raise CoQ10 levels in the blood. This increase is important because higher CoQ10 levels are linked to better heart health and lower blood pressure. Some research suggests that CoQ10 might reduce systolic blood pressure by about 4 to 5 mmHg, particularly in individuals with heart issues. While results can vary, CoQ10 generally helps people with low CoQ10 levels by restoring these levels in the body. In this trial, participants will receive either a high absorption CoQ10 product or a standard CoQ10 product. The high absorption CoQ10 product aims to enhance these benefits by improving the body's absorption of CoQ10.678910

Are You a Good Fit for This Trial?

This trial is for healthy men and women aged 21-65 with a BMI between 18.5 and 34.9, who are not pregnant or breastfeeding, do not smoke regularly, have no major health issues (like heart, liver, kidney disease), aren't on certain medications or supplements affecting CoQ10, and can stop taking other supplements before the study.

Inclusion Criteria

I am between 21 and 65 years old.
Individual is judged by the Investigator to be in generally good health on the basis of medical history and screening/baseline measurements
Individual has a score of 7 or higher on the Vein Access Scale
See 3 more

Exclusion Criteria

Individual has been exposed to any non-registered drug product within 30 days prior to screening/baseline (visit 1)
Individual has a current or recent history or strong potential for illicit drug or excessive alcohol intake defined as >14 drinks per week
I have or had serious hormone, heart, lung, kidney, liver, or bile duct problems.
See 15 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week
1 visit (in-person)

Test 1

Participants consume the first study product with a standardized meal, followed by blood sampling over 10 hours

2 days
2 visits (in-person)

Test 2

Participants consume the second study product with a standardized meal, followed by blood sampling over 10 hours

2 days
2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

What Are the Treatments Tested in This Trial?

Interventions

  • high absorption CoQ10 product
  • standard CoQ10 product

Trial Overview

The study compares how well two types of Coenzyme Q10 (CoQ10)—one designed for better absorption and one standard—are absorbed in the body after a single dose. Each participant tries both products at different times while their blood levels are measured.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Experimental - high absorption CoQ10 productExperimental Treatment1 Intervention
Group II: Active Comparator - standard CoQ10 productActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Midwest Center for Metabolic and Cardiovascular Research

Lead Sponsor

Trials
22
Recruited
880+

Pharmavite LLC

Industry Sponsor

Trials
12
Recruited
27,200+

Citations

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