Mobile Messaging for Colorectal Cancer Screening

(CoSMMO Trial)

Not yet recruiting at 3 trial locations
YS
Overseen ByYamila Sierra
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Colorado, Denver
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to develop and test a text message program that encourages patients to complete at-home screenings for colorectal cancer and ensures they receive follow-up care if needed. The trial will explore various message types, such as Autonomy Support Outreach, Impediments Support Outreach, Live Support Outreach, and Personalized Text Messages, to determine which ones most effectively engage patients and increase the completion rate of cancer screenings. Patients who have received an at-home colorectal cancer screening kit order and are at average risk, without a personal or family history of related issues, may be suitable for this trial. Participants should also have a mobile phone to receive text messages. As an unphased trial, this study provides an opportunity to contribute to innovative approaches in preventive healthcare.

Do I have to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It seems focused on testing a text message program for colorectal cancer screening, so it's unlikely that your medications would be affected.

What prior data suggests that this text message program is safe for encouraging colorectal cancer screening?

Research has shown that using text messages to encourage colorectal cancer screening is generally safe and well-received. Text messaging boosts participation in screening programs without causing harm. For instance, studies have found that motivational text messages significantly increase the completion of fecal immunochemical tests (FIT), which check for colorectal cancer. Text messaging is also considered an acceptable way to involve patients in screening decisions.

Specific methods, such as personalized text messages and live support, have been used in past research without reported negative effects. Additionally, offering help to overcome screening obstacles has effectively increased participation without safety concerns.

Since these interventions involve sending messages rather than administering medications or performing medical procedures, the risk of harm remains low. This makes text messaging a safe option for encouraging more people to get screened for colorectal cancer.12345

Why are researchers excited about this trial?

Researchers are excited about this trial because it explores how different types of mobile messaging can impact colorectal cancer screening rates. Unlike traditional methods that rely on standard reminders, this trial tests personalized messages and support systems, including autonomy and live support, to see if they can better address individuals' concerns and motivations. By tailoring messages to address personal anxieties and leveraging different support mechanisms, the trial aims to uncover whether these innovative communication strategies can improve screening participation, potentially leading to earlier detection and better outcomes for patients.

What evidence suggests that this trial's treatments could be effective for colorectal cancer screening?

This trial will evaluate various mobile messaging strategies to increase colorectal cancer screening rates. Studies have shown that sending messages to phones can boost the number of people getting screened for colorectal cancer. One study with veterans found that automated text reminders increased screening completion from 28% to 38% in just 90 days. Another study reported a 42% increase in screening rates in Alaska Native clinics due to text reminders. Additionally, reminders sent through the mail have effectively led to more completed tests. Personalized text messages, especially those tailored to encourage specific behaviors, have also been linked to higher participation in screenings. These findings suggest that mobile messaging is a promising way to encourage more people to complete their at-home colorectal cancer screenings. This trial will test different messaging approaches, including personalized and gain-framed messages, to determine the most effective strategy.46789

Who Is on the Research Team?

GK

Gina Kruse, MD

Principal Investigator

University of Colorado, Denver

Are You a Good Fit for This Trial?

This trial is for adults aged 45-75 who get care at participating community health centers, are at average risk for colorectal cancer, have been given an at-home stool test order by their doctor, and can receive text messages on their phone.

Inclusion Criteria

Eligibility Criteria for CHC Patients Cohorts
I am between 45 and 75 years old.
* Receive care in partner CHCs
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Message Optimization

Clinic patients and staff participate in focus groups and interviews to design the text message program.

4 weeks
Focus groups and interviews

First Factorial Experiment

Testing different message versions for engagement with 2,000 patients.

14 days

Second Factorial Experiment

Optimizing outreach strategy for CRC screening completion with 5,100 patients.

3 months

Follow-up

Participants are monitored for follow-up care after abnormal stool-based screening test.

3 months

Implementation and Sustainment Assessment

Assessing implementation outcomes and sustainment of intervention components.

12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Autonomy Support Outreach
  • Data Reporting and Visualization System Tools
  • Impediments Support Outreach
  • Live Support Outreach
  • Personalized Text Message

Trial Overview

The study is testing different types of supportive and personalized text messages sent through the clinic's electronic system to see which ones best encourage patients to complete home colorectal cancer screening tests.

How Is the Trial Designed?

16

Treatment groups

Experimental Treatment

Group I: Standard Message - No Gain FrameExperimental Treatment2 Interventions
Group II: Standard Message - Gain FrameExperimental Treatment2 Interventions
Group III: Personalized Message - No Gain FrameExperimental Treatment3 Interventions
Group IV: Personalized Message - Gain FrameExperimental Treatment3 Interventions
Group V: Personalized - Concern Message - No Gain FrameExperimental Treatment3 Interventions
Group VI: Personalized - Concern Message - Gain FrameExperimental Treatment3 Interventions
Group VII: Outreach + Live SupportExperimental Treatment2 Interventions
Group VIII: Outreach + Impediments SupportExperimental Treatment2 Interventions
Group IX: Outreach + Impediments + Live SupportExperimental Treatment3 Interventions
Group X: Concern Message - No Gain FrameExperimental Treatment3 Interventions
Group XI: Concern Message - Gain FrameExperimental Treatment3 Interventions
Group XII: Basic Outreach OnlyExperimental Treatment2 Interventions
Group XIII: Autonomy Outreach SupportExperimental Treatment2 Interventions
Group XIV: Autonomy + Live SupportExperimental Treatment3 Interventions
Group XV: Autonomy + Impediments SupportExperimental Treatment3 Interventions
Group XVI: Autonomy + Impediments + Live SupportExperimental Treatment4 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials
1,842
Recruited
3,028,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+

Massachusetts League of Community Health Centers

Collaborator

Trials
1
Recruited
6+

Dana-Farber Cancer Institute

Collaborator

Trials
1,128
Recruited
382,000+

University of Texas Southwestern Medical Center

Collaborator

Trials
1,102
Recruited
1,077,000+

Massachusetts General Hospital

Collaborator

Trials
3,066
Recruited
13,430,000+

Citations

Qualitative Outcomes of Colorectal Cancer Screening ... - PMC

[35] that the patient navigation component of SMARTER CRC was effective at 6 months; among the 34 enrollees, follow-up colonoscopy completion ...

Effectiveness of a Mailed Colorectal Cancer Screening ... - PMC

A mailed FIT outreach program resulted in a 3.4 percentage point increase in FIT completion in clinics that received the intervention, compared with clinics ...

Comparative Effectiveness Pilot Trial of Mailed Cologuard ...

Support, and Colorectal Cancer Screening Uptake Among African American Men: A. Systematic Review. American Journal of Men's Health. 2017;11(5): ...

Randomised trial to evaluate the effectiveness and impact ...

Effectiveness will be evaluated by comparing screening use, as documented in the EHR, between trial enrollees in the e-assist: Colon Health and usual care plus ...

Impact of Social Support on Colorectal Cancer Screening ...

The results of this study suggest that social support is an effective method to increase colorectal cancer screening rates among Latinos. ... Third, missing data ...

Behaviorally Informed Text Messaging to Promote Colon ...

These findings suggest that automated, behaviorally informed text messages were associated with significantly improved FIT completion compared ...

Exploring the Acceptability of Text Messages to Inform and ...

Findings from this study demonstrate the general acceptance of text messages to engage patients in decisions regarding CRC screening as well as ...

Text Messages Boost Colon Cancer Screening Uptake

Within 21 days, 58.9% of patients in the text message group completed their screening, compared with 49.8% in the telephone group. This 9% ...

Study Finds Personalized Risk Messages Had No Effect in ...

The researchers analyzed data from 214 providers and 1,084 patients at average risk for colorectal cancer across 41 primary care clinics in two ...