EVOO Supplements for Mild Cognitive Impairment

(ATHENA Trial)

This trial tests whether a dietary supplement made from extra-virgin olive oil (EVOO) can improve memory and other brain functions in people with mild cognitive impairment (MCI). Researchers aim to determine if EVOO supplements affect memory and brain-related markers, such as blood vessel health. Participants will take either the EVOO-phenolics dietary supplement or a placebo (a pill that looks the same but contains no active ingredients) for six months. This trial may suit individuals experiencing mild memory issues without major strokes or severe brain injuries. As an unphased trial, it offers an opportunity to contribute to early-stage research on dietary supplements and brain health.

Research shows that extra-virgin olive oil (EVOO) supplements are generally safe to consume. Studies have found that people tolerate the polyphenols in EVOO well. For instance, research indicates that individuals who consume diets rich in olive oil, including EVOO, often experience improved brain function without major safety concerns. Additionally, olive oil has been linked to a lower risk of memory problems, suggesting it is both safe and beneficial. This evidence suggests that EVOO supplements are likely safe, with no significant side effects reported in studies.¹²³⁴⁵

Unlike standard treatments for mild cognitive impairment that often focus on medications to improve neurotransmitter function, such as cholinesterase inhibitors or memantine, the EVOO phenolics supplement introduces a novel approach using active compounds derived from extra virgin olive oil. These phenolics have antioxidant and anti-inflammatory properties, potentially providing neuroprotective benefits. Researchers are excited because this natural supplement could offer a gentler, more holistic alternative that targets brain health differently, with fewer side effects than traditional medications.

Research has shown that extra-virgin olive oil (EVOO) might improve brain function in people with mild memory problems. One study found that regularly consuming EVOO maintained brain health better than some other foods, such as nuts. This benefit arises from EVOO's natural compounds called polyphenols, which are linked to better brain health and slower memory decline. Another study found that a Mediterranean diet, which includes EVOO, improved brain function in people with mild memory issues. This trial will test an EVOO-phenolics dietary supplement to evaluate its potential as a promising option for supporting memory and brain health.²⁴⁶⁷⁸