Computerized Cognitive Training for Mild Cognitive Impairment

(INHANCE-MCI Trial)

This trial tests two computerized programs aimed at boosting brain function in older adults with mild cognitive impairment (MCI). The goal is to determine if these programs can improve thinking skills and overall brain health. Participants will engage in either speed training or executive function training sessions on a computer. Suitable candidates are individuals aged 65 or older who have MCI, experience memory or thinking issues, and can use a computer. As an unphased trial, this study allows participants to contribute to innovative research that could enhance cognitive health for many.

The trial does not specify that you need to stop taking your current medications. However, if you are taking medications typically prescribed for dementia, like Donepezil or Memantine, your dose must be stable for at least 12 weeks before joining the study.

Previous studies have found computerized cognitive training programs to be safe for people with mild cognitive impairment (MCI). Research shows that participants generally tolerate these programs well. For instance, one study found that 77% of participants completed a challenging training schedule, which involved sessions lasting 90-100 minutes a day, five days a week for six weeks. This suggests that most people can handle the programs.

For computerized speed-based cognitive training, studies have shown promising results. Participants who completed speed training had a 29% lower risk of developing dementia over ten years. This indicates effectiveness and suggests a positive safety profile, as no significant negative effects were reported.

Similarly, studies suggest that computerized executive function cognitive training is a safe way to improve thinking skills in older adults with MCI. A review found that these programs can enhance overall brain health without reported negative side effects.

Researchers are excited about the computerized cognitive training for mild cognitive impairment because it offers a non-invasive and engaging way to potentially enhance brain function, compared to traditional methods like medication or therapy. Unlike current treatments that might focus on slowing down symptoms, these computerized programs aim to actively boost specific cognitive abilities such as processing speed and executive functions. By using software that adapts to each user's performance, these training sessions can provide a personalized approach, possibly leading to more effective outcomes. Additionally, the convenience of accessing these programs from home makes them an attractive option for consistent, long-term use.

Research has shown that computerized brain training can assist people with mild cognitive impairment (MCI). In this trial, participants will join one of two training programs. Studies found that those in the Speed Training arm who completed speed-based cognitive training had a 29% lower risk of developing dementia. Participants also improved in memory for words and pictures, along with better overall thinking skills. Meanwhile, those in the Executive Function Training arm will engage in training aimed at enhancing planning and organization skills, which has been shown to aid in managing time, paying attention, and remembering things. Various studies have indicated that both types of training lead to moderate improvements in thinking abilities for people with MCI. Overall, these brain training programs are promising tools for boosting mental abilities in older adults with MCI.⁶⁷⁸⁹¹⁰