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Transcranial Focused Ultrasound for Cocaine Addiction

Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: Mary Phillips, MD MD (Cantab)
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The investigators aim to examine the effect of transcranial focused ultrasound (tFUS) on brain activity and cocaine craving in adults with cocaine use disorder.

Who Is on the Research Team?

ML

Mary L Phillips

Principal Investigator

University of Pittsburgh

Are You a Good Fit for This Trial?

This trial is for adults who have a cocaine use disorder. People with certain medical or psychiatric conditions, or those who do not meet safety requirements for brain stimulation, may not be able to participate.

Inclusion Criteria

Uses cocaine as a primary drug at a minimum frequency of 1x/mo; any period of abstinence within the past month does not exceed 1 week
I am between 18 and 45 years old.

Exclusion Criteria

I am not between 18 and 45 years old.
Present or lifetime history of primary psychosis or Bipolar Disorder (DSM-5 criteria, SCID-5, SCID-5-PD, YMRS>10), present suicidal ideation, or current depressive episode
History of head injury, neurological disorders (e.g., epilepsy), pervasive developmental disorder (e.g., autism), systemic medical disease and treatment (medical records, participant report)
See 12 more

What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Focused Ultrasound (tFUS)

Trial Overview

The study is testing transcranial focused ultrasound (tFUS), a non-invasive technique that uses sound waves on the brain, compared to a sham (inactive) version. The goal is to see if tFUS changes brain activity and reduces cocaine cravings.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: VS tFUS/Sham tFUSExperimental Treatment2 Interventions
Group II: Sham tFUS/VS tFUSExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mary Phillips, MD MD (Cantab)

Lead Sponsor

Trials
4
Recruited
180+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials
2,658
Recruited
3,409,000+

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