200 Participants NeededMy employer runs this trial

Postnatal Exercise for Infant Obesity Prevention

(PEABaBy Trial)

Recruiting at 1 trial location
EM
SC
Overseen ByStudy Coordinator
Age: 18 - 65
Sex: Female
Trial Phase: Academic
Sponsor: Joslin Diabetes Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how exercise during and after pregnancy might alter breast milk to help infants manage energy and potentially prevent obesity. Researchers aim to determine if maternal exercise influences infant growth and weight. Participants will either continue their usual care routine or engage in daily physical activity (postnatal exercise). Ideal candidates are women with a single, uncomplicated pregnancy who plan to exclusively breastfeed for more than three months and have previously done so successfully.

As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could benefit future mothers and infants.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your healthcare provider.

What prior data suggests that postnatal exercise is safe for mothers and infants?

Research has shown that exercising after childbirth is safe and well-received by new mothers. Studies have found that physical activity post-childbirth improves heart health and does not impact the amount or quality of breast milk. It also supports normal baby growth and is safe for the mother. Exercising after giving birth can help mothers regain fitness and lose extra pregnancy weight, benefiting both mother and baby. Reports of major negative effects from these exercise programs are absent.12345

Why are researchers excited about this trial?

Researchers are excited about postnatal exercise as a method for preventing infant obesity because it focuses on enhancing physical activity for new mothers, potentially influencing their babies' health from a very early stage. Unlike standard treatments for obesity, which might include dietary changes or medical interventions, this approach emphasizes increasing physical activity in a natural, daily routine. The novelty lies in its preventative nature, targeting the root of obesity by promoting an active lifestyle from the postnatal period, which could set healthier patterns for both the mother and child.

What evidence suggests that postnatal exercise might be effective for infant obesity prevention?

This trial will compare enhanced physical activity with usual care for new mothers. Studies have shown that exercising during and after pregnancy can lower the risk of obesity in children. Research suggests that maternal exercise boosts a baby's metabolism, promoting healthier weight and development. Exercise programs effectively manage weight in both pregnant and new mothers. Additionally, exercise improves the body's ability to handle sugar, which is crucial for overall health. These findings suggest that regular exercise for new mothers might positively affect their breast milk, helping to prevent obesity in their babies.36789

Are You a Good Fit for This Trial?

This trial is for pregnant women aged 18-45 with a BMI between 18.5 and 40, expecting one baby at term (37–42 weeks), planning to breastfeed exclusively for over 3 months, and having an uncomplicated pregnancy. Their newborn must be above the 10th percentile in birth weight.

Inclusion Criteria

I am between 18 and 45 years old.
My BMI before pregnancy or in the first trimester is between 18.5 and 40.
* Intention to exclusively breastfeed for \>3 months and, if parity \>1, that they successfully breastfed a previous pregnancy
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in enhanced physical activity and undergo supervised bouts of acute moderate exercise

8 weeks
Regular visits for exercise supervision and milk composition analysis

Follow-up

Participants are monitored for changes in infant growth, body composition, and energy expenditure

12 months
Visits at 1, 3, 6, and 12 months for infant assessments

What Are the Treatments Tested in This Trial?

Interventions

  • Postnatal Exercise

Trial Overview

The study looks at how exercise during and after pregnancy affects breast milk composition and whether these changes influence infant growth, energy use, and obesity risk. Participants are assigned to an active group that follows specific physical activity routines.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: Enhanced physical activityExperimental Treatment1 Intervention
Group II: Control groupActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Joslin Diabetes Center

Lead Sponsor

Trials
98
Recruited
26,500+

University of Oklahoma

Collaborator

Trials
484
Recruited
95,900+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+

Citations

The Effects of Physical Activity and Physical Activity plus Diet ...

We found that PA interventions were effective for OW/OB pregnant as well as postpartum women. On average, pregnant women in the intervention groups gained 0.91 ...

Impact of physical activity on maternal and neonatal outcomes ...

The aim of this study was to evaluate the impact of physical activity before and during pregnancy on maternal perinatal outcomes and neonatal condition.

From Pregnancy to Breastfeeding: The Role of Maternal ...

Maternal exercise during pregnancy and breastfeeding significantly reduces the risk of childhood obesity by enhancing fetal metabolism.

Impact of physical activity on course and outcome ...

Overall, animal studies have shown that exercise improves insulin sensitivity, lipid metabolism and glucose tolerance in diabetic and obese ...

Effects of a behavioral intervention on physical activity, diet ...

Effectiveness of exercise interventions in the prevention of excessive gestational weight gain and postpartum weight retention: a systematic ...

Early Prevention of Childhood Obesity: Impact of Maternal ...

At six months post-partum, obese women in the intervention group retained less than 1% of their maternal weight compared to 7% weight retention among obese ...

Physical Activity during Pregnancy and Childhood Obesity

Our findings indicate that physical activity during pregnancy did not significantly alter the birthweight or BMI during the early years of life, which is ...

Postnatal Exercise for Infant Obesity Prevention

This study can help investigators learn more about how maternal exercise patterns may affect body growth and obesity risk in infants who are ...

The Role of Maternal Exercise in Preventing Childhood Obesity

Maternal exercise during pregnancy and breastfeeding significantly reduces the risk of childhood obesity by enhancing fetal metabolism, supporting healthy ...