Contrast-Enhanced CBCT for Cancer

(IV-CBCT Trial)

This trial tests a new method to guide radiotherapy for cancer patients using an enhanced imaging technique called intravenous contrast-enhanced cone beam computed tomography (IV CBCT). The goal is to determine if this technique improves the visibility of cancer targets during treatment. Participants will undergo special scans before and during their radiation therapy sessions. The trial seeks individuals with confirmed cancer who plan to undergo a specific type of radiation treatment and can safely receive the contrast dye used in the scans. As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance cancer treatment visualization.

A previous study found that using a special type of CT scan called intravenous contrast-enhanced cone beam computed tomography (IV CBCT) helped doctors see tumors more clearly. This improved visibility aids in planning treatment. Regarding safety, patients usually tolerate the use of IV contrast in these scans well. Some people might feel a warm sensation or notice a metallic taste, but serious reactions are rare.

Contrast-enhanced cone beam computed tomography (CBCT) is unique because it offers a more detailed imaging method for cancer detection and monitoring. Unlike traditional imaging techniques, such as standard CT or MRI, this method uses an intravenous contrast to enhance the visibility of tumors, potentially leading to earlier and more accurate detection. Researchers are excited about this technique because it could improve the precision of cancer diagnosis, allowing for better treatment planning and outcomes. This advancement also has the potential to reduce radiation exposure compared to traditional CT scans, making it a safer option for patients.

Research has shown that intravenous contrast-enhanced cone beam computed tomography (IV CBCT) can enhance tumor visibility, particularly in the liver during breath-hold scans. In a study with 7 patients, tumor visibility improved with IV contrast. Another study found that IV CBCT outperformed other imaging methods for specific tasks, such as examining stents and blood vessel walls when other methods were less effective. Additionally, CBCT is more sensitive than other imaging techniques in detecting tumors and their blood supply. This trial will evaluate the effectiveness of IV CBCT, which could become a valuable tool for improving tumor imaging precision, especially in radiotherapy planning.¹²³⁶⁷