Pomegranate Supplement for Burnout

This trial aims to determine if Pomella pomegranate extract can reduce stress and improve well-being in medical students and residents. Researchers will compare the effects of a pomegranate supplement with a placebo (a pill with no active ingredients) over 28 days. The goal is to discover if the antioxidants in pomegranate can help manage the stress and fatigue of medical training. The study seeks first or second-year medical students or residents at the University of Mississippi Medical Center who are not taking other medications or supplements and do not have severe depression or anxiety. As an unphased trial, it offers participants the chance to contribute to understanding the potential benefits of natural supplements in stress management.

Yes, you will need to stop taking any chronic medications and supplements, including over-the-counter multivitamins, to participate in this trial.

Research has shown that Pomella pomegranate extract is safe for people. One study found that even at high doses, Pomella did not cause harm. Specifically, taking up to 600 mg per kilogram of body weight each day did not result in adverse effects. This amount exceeds what is used in clinical trials, indicating good tolerance.

Other studies have examined pomegranate products and found them safe for humans, with no major reports of unwanted side effects or reactions.

Unlike the standard treatments for burnout, which often involve therapy or medication like antidepressants, the Pomella pomegranate extract offers a natural approach. This supplement is unique because it harnesses the power of pomegranate, known for its antioxidant properties, to potentially reduce stress and fatigue. Researchers are excited about this treatment because it could provide a simpler, plant-based alternative with fewer side effects than conventional medications. Plus, the promise of noticeable effects within just 28 days makes it an appealing option for those seeking quicker relief.

Research has shown that Pomella pomegranate extract is rich in antioxidants, which protect the body from damage. This damage, known as oxidative stress, links to various health problems, including mental distress. One study found that Pomella improved skin health and reduced signs of oxidative stress in the body. This trial will test Pomella pomegranate extract as one treatment arm, suggesting it might also help with stress-related issues, like burnout. The extract contains natural plant compounds called polyphenols, which support brain health and improve overall well-being. Participants in another arm will receive a placebo for comparison.⁵⁶⁷⁸⁹