CPAP for Bronchopulmonary Dysplasia
(CPAP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.
Who Is on the Research Team?
Colm P. Travers, MD
Principal Investigator
University of Alabama at Birmingham
Are You a Good Fit for This Trial?
This trial is for premature infants born before 29 weeks who are less than 32 weeks old at the time of joining, currently on CPAP with stable breathing and oxygen needs, have been off a ventilator for at least 72 hours if previously intubated, and whose parents or guardians give consent.Inclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- CPAP
- Nasal Cannula
Trial Overview
The study compares keeping babies on CPAP longer versus switching them earlier to a nasal cannula. It aims to see which approach better prevents lung problems (bronchopulmonary dysplasia) or death by 36 weeks' age.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
CPAP will be provided via mask or binasal prongs to maintain a relatively uniform CPAP delivery system among infants in the treatment group. Bubble CPAP will be preferred over other modes of CPAP delivery whenever available.
HFNC at 4 L/min will be used initially in the control group. Flow should be titrated down by 1 L/min per day until ≤0.5 L/kg among infants in the nasal cannula group if not meeting pre-specified failure criteria to reduce the risk of inadvertent positive end-expiratory pressure (PEEP). Flow can also be increased (up to 6 L/min maximum) if needed among infants on NC who meet the pre-specified failure criteria. Infants in the control group placed back on CPAP may use an interface at provider discretion.
Find a Clinic Near You
Who Is Running the Clinical Trial?
NICHD Neonatal Research Network
Lead Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator
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