Mindfulness for GVHD
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether mindfulness practices can improve the well-being of individuals with chronic graft-versus-host disease (cGVHD). cGVHD occurs when donated stem cells attack the recipient's body after a transplant, leading to issues such as pain, itching, and sleep disturbances. Participants will engage in group and individual mindfulness relaxation sessions to determine if these practices alleviate symptoms and enhance quality of life. This trial suits those diagnosed with moderate to severe cGVHD who are willing to attend sessions and can read and understand English. As an unphased trial, it offers participants a unique opportunity to explore innovative ways to manage symptoms and improve well-being.
What prior data suggests that this mindfulness intervention is safe for patients with chronic graft versus host disease?
Research shows that mindfulness activities are generally safe. Studies have found that they can lower stress and boost emotional well-being without harmful side effects. For example, people with long-term conditions like graft-versus-host disease (GVHD) often use meditation and relaxation techniques to manage stress and improve their quality of life.
Mindfulness practices, like those tested in the trial, usually include breathing exercises, meditation, and visualization. These methods are non-invasive, meaning they don't involve surgery or medication, and people usually handle them well. Research has not reported any major negative effects from these practices.
In summary, mindfulness relaxation is considered a safe way to manage symptoms and stress, especially for those with chronic health issues.12345Why are researchers excited about this trial?
Researchers are excited about using mindfulness relaxation for GVHD (Graft-Versus-Host Disease) because it offers a new, non-pharmacological approach to managing this condition. Unlike traditional treatments that often rely on immunosuppressive drugs, mindfulness relaxation focuses on stress reduction techniques such as diaphragmatic breathing and meditation, which can potentially enhance patients' overall well-being without the side effects associated with medications. Additionally, this method encourages daily self-meditation, empowering patients to take an active role in their own care. By incorporating these holistic practices, the treatment could complement existing therapies and improve quality of life for those with GVHD.
What evidence suggests that this mindfulness intervention is effective for reducing symptoms of cGVHD?
Research has shown that mindfulness practices can reduce stress and improve quality of life for various health issues. Studies have found that these techniques ease symptoms like pain, anxiety, and depression by promoting relaxation and emotional balance. In this trial, participants will engage in mindfulness-based interventions, which may help those with chronic graft-versus-host disease (cGVHD) manage symptoms such as joint pain and trouble sleeping. Early findings suggest that meditation and breathing exercises can reduce stress and enhance emotional coping. This approach might improve overall well-being for people with cGVHD.
Who Is on the Research Team?
Amandeep Salhotra
Principal Investigator
City of Hope Medical Center
Are You a Good Fit for This Trial?
This trial is for people who have chronic graft-versus-host disease (cGVHD) after receiving a stem cell transplant from a donor. Participants should be experiencing symptoms like pain, stiffness, or emotional distress related to cGVHD.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Mindfulness-Based Intervention
Participants complete an 8-week mindfulness-based intervention program consisting of weekly group sessions and a practitioner/patient 1:1 session. Sessions include instruction on diaphragmatic breathing, body scan, visualization, and individual meditation practice.
Follow-up
Participants are monitored for safety and effectiveness after the mindfulness-based intervention program
What Are the Treatments Tested in This Trial?
Interventions
- Mindfulness Relaxation
Trial Overview
The study is testing whether mindfulness-based stress reduction—through group and individual sessions—can help reduce symptoms reported by patients with cGVHD. It also includes surveys and biospecimen collection to track changes.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients complete group sessions QW, on weeks 1-4, over 40 minutes, and on weeks 6-8, over 60 minutes, and an individual session, over 60 minutes, on week 5. Sessions consist of instruction on diaphragmatic breathing, body scan, visualization, and individual mediation practice. Patients are recommended to complete self mediation daily for at least 15 minutes, for 8 weeks. Patients undergo blood sample collection throughout the study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
City of Hope Medical Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Citations
Mindfulness Intervention to Reduce Patient Reported ...
This clinical trial tests a mindfulness intervention, consisting of group sessions and an individual session, using mindfulness based stress ...
2.
cancernursingtoday.com
cancernursingtoday.com/post/mindfulness-meditation-for-people-with-gvhd-and-their-caregiversMindfulness Meditation for People With GVHD and Their ...
Research suggests that mindfulness interventions may be beneficial for SCT patients and caregivers. Although data is limited for GVHD survivors,
Mindfulness Intervention to Reduce Patient Reported ...
This clinical trial tests a mindfulness intervention, consisting of group sessions and an individual session, using mindfulness based stress reduction ...
eHealth Mindfulness-based Music Therapy for Patients ... - PMC
These treatments can have a wide range of negative side effects (e.g., nausea, pain, fatigue, mood disturbance, risk of infections) [2]. Post-transplant ...
eHealth mindfulness-based music therapy for patients ...
These treatments can have a wide range of negative side effects (e.g., nausea, pain, fatigue, mood disturbance, risk of infections) [2]. Post-transplant ...
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.