Indocyanine Green Imaging for Lymphedema in Breast Cancer

This trial aims to determine if inserting an IV line and administering fluids affects the lymphatic system in breast cancer patients who might develop lymphedema (arm swelling due to fluid buildup) after surgery. Researchers use a special dye called indocyanine green (ICG) and a camera system to assess blood flow in the arm. This trial is for breast cancer patients who underwent axillary dissection surgery at least a year ago and have difficulty using their other arm for blood draws. As an unphased trial, it offers patients the opportunity to contribute to important research that could enhance post-surgical care for breast cancer patients.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that Indocyanine Green (ICG) is safe and commonly used in studies on lymphedema related to breast cancer. It helps doctors assess the lymphatic system, which clears toxins and waste from the body. Studies indicate that most people tolerate ICG well, with few experiencing adverse reactions. Specifically, ICG has proven useful in reducing lymphedema, the swelling from fluid buildup, in breast cancer survivors, highlighting its safety. Although some may worry about side effects, evidence suggests that ICG is a safe option for those considering participation in a clinical trial.¹²³⁴⁵

Researchers are excited about using Indocyanine Green (ICG) imaging for lymphedema in breast cancer patients because it offers a new way to visualize lymphatic function and fluid accumulation. Unlike traditional treatments that focus on managing symptoms with compression garments and physical therapy, ICG provides real-time imaging to better assess and monitor the condition's progression. This approach could lead to more personalized and effective management plans by identifying specific areas of lymphatic blockage. Additionally, ICG imaging is non-invasive and can be repeated over time, making it a promising tool for ongoing assessment without the need for more invasive procedures.

Research has shown that indocyanine green (ICG) lymphography can detect lymphatic system issues before swelling, known as edema, becomes visible. In this trial, participants will receive ICG dye and undergo imaging and lymphedema assessments at various intervals. Studies have found that ICG imaging predicts changes in arm size and composition more effectively than clinical exams for those with breast cancer-related lymphedema (BCRL). This capability may help identify issues early and guide preventive measures. Other research indicates that ICG-guided treatments can reduce the risk of developing lymphedema and improve quality of life for high-risk individuals. Overall, these findings suggest that ICG imaging effectively assesses and possibly prevents BCRL.²⁴⁵⁶⁷