100 Participants NeededMy employer runs this trial

Leptin-Supporting Supplement for Weight Changes

MA
Overseen ByMatthew Amsden
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how a leptin-supporting supplement, the Leptin Balance Formula, affects hunger and body changes over 12 weeks. Leptin, a hormone that regulates appetite, may help manage weight when supported by this supplement. Participants will take the supplement daily and track changes in appetite and weight. This trial suits adults willing to try the supplement for 12 weeks and complete online surveys about their experience.

As an unphased trial, this study provides a unique opportunity to contribute to understanding how this supplement might support weight management.

Do I have to stop taking my current medications?

The trial does not clearly state if you must stop taking your current medications. However, if you are using medications or supplements that could affect appetite or weight, you need medical clearance to participate.

What prior data suggests that this supplement is safe for use?

Studies have shown that leptin, a hormone that controls hunger and weight, is safe for humans. The body naturally produces leptin to help manage appetite. Research indicates that leptin can reduce hunger but does not alter energy expenditure.

In human studies, leptin treatment typically benefits individuals with naturally low leptin levels. These studies report no significant serious side effects related to leptin. However, while leptin can help control appetite, it does not necessarily lead to weight loss on its own.

Overall, the Leptin Balance Formula, which supports leptin's function in the body, appears well-tolerated according to current research. Studies about leptin itself have reported no major safety concerns, suggesting that this supplement is likely safe for general use.12345

Why are researchers excited about this trial?

Unlike the standard weight management treatments that often rely on calorie restriction or increased physical activity, the Leptin Balance Formula focuses on supporting the body's natural leptin function. Leptin is a hormone that plays a crucial role in regulating hunger and energy balance. Researchers are excited about this treatment because it targets the underlying hormonal imbalances that can contribute to weight changes, potentially offering a more sustainable and less restrictive approach to weight management. This novel mechanism of action, which enhances leptin's effectiveness, sets it apart from traditional methods that primarily focus on diet and exercise alone.

What evidence suggests that this supplement might be an effective treatment for weight changes?

Research has shown that leptin plays a crucial role in controlling hunger and energy levels. For individuals with leptin deficiency, treatment can reduce hunger, but it does not appear to alter energy expenditure. Some studies suggest that lowering leptin levels can lead to weight loss. However, leptin treatment may not be effective for everyone, particularly those with leptin resistance, where the body does not respond well to leptin signals. In cases of obesity, leptin alone may not result in significant weight loss. Overall, its effectiveness depends on individual factors, such as leptin sensitivity. Participants in this trial will receive the Leptin Balance Formula to evaluate its effects on weight changes.14678

Are You a Good Fit for This Trial?

This trial is for adults aged 18 or older who are willing to take a leptin-supporting dietary supplement daily for 12 weeks, pay for the product, and complete online questionnaires. People can't join if they're pregnant, breastfeeding, have allergies to the supplement, certain medical conditions, or use appetite/weight-affecting meds without clearance.

Inclusion Criteria

I am willing to pay for study supplies and take a supplement every day for 12 weeks.
I am 18 years old or older.
Willing to complete electronic questionnaires and self-reported measurements
See 1 more

Exclusion Criteria

I am not taking any drugs or supplements that affect my appetite or weight without my doctor's approval.
Any medical condition that would make participation unsafe, as determined by the participant
Known allergy or sensitivity to any supplement ingredients
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants self-administer the Leptin Balance Formula supplement daily and complete periodic self-reported assessments

12 weeks
Baseline, Week 4, Week 8, and Week 12 (self-reported assessments)

Follow-up

Participants are monitored for changes in hunger perception and body weight after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Leptin Balance Formula

Trial Overview

The study tests a commercially available Leptin Balance Formula supplement taken daily for 12 weeks. Participants track their own hunger and weight changes before and after using the supplement; there is no separate control group.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Single Arm longitudinal where participants act as their own controlExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Efforia, Inc

Lead Sponsor

Trials
3
Recruited
1,200+

Citations

The Effect of a Leptin Phenotype on Weight Change and ...

We found no association between leptin phenotypes and energy expenditure or weight change either cross-sectionally or in response to acute or prolonged over- or ...

The Effect of a Leptin Phenotype on Weight Change and ...

Moreover, leptin phenotype was not a determinant of weight change in response to energy restriction or surplus, or subsequent weight recovery.

The Leptin System and Diet: A Mini Review of the Current ...

Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity leads to leptin resistance, exacerbating overeating.

Evidence from clinical studies of leptin: current and future ...

Leptin treatment is effective only in conditions of leptin deficiency. Leptin reduces appetite but has no effect on energy expenditure in humans.

Evidence from clinical studies of leptin: current and future ...

In summary, leptin treatment is very effective at improving insulin sensitivity, hyperglycemia, hypertriglyceridemia and hepatic steatosis in lipodystrophies, ...

Researchers discover a cause of leptin resistance—and ...

The drug rapamycin restores leptin sensitivity to diet-induced obese mice, leading to significant loss of fat with only minimal effects on muscle.

Longitudinal Analysis of Leptin Variation during Weight ... - PMC

The disproportionate reduction of leptin seen during weight loss recovered after weight loss. Leptin increases mirrored increases in BMI SDS during weight ...

Leptin alters energy intake and fat mass but not ...

Based on studies in mice, leptin was expected to decrease body weight in obese individuals. However, the majority of the obese are ...