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Transcranial Magnetic Stimulation for Cerebellar Ataxia

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DH
Overseen ByDebbie Harrington, BS, CCRP
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: George Wittenberg
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The work will examine the mechanisms and potential therapeutic effects of transcranial magnetic stimulation on upper-limb sensorimotor function in individuals with cerebellar dysfunction, including those with damage due to stroke or autoimmune disease.

The study team will work toward a goal of non-invasive stimulation-based neuromodulatory interventions for cerebellar disorders using a closely integrated, clinically oriented cross-species approach. There will be a related study in nonhuman primates.

Who Is on the Research Team?

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Jorge A González-Martinez, MD, PhD

Principal Investigator

University of Pittsburgh

Are You a Good Fit for This Trial?

This trial is for people who have movement problems due to cerebellar damage, such as from a stroke or certain diseases affecting the cerebellum. Participants should be adults with upper limb coordination issues caused by this type of brain injury.

Inclusion Criteria

Medically stable to participate in the study
Native English speakers
I am between 18 and 100 years old.
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Exclusion Criteria

Have any factor that precludes participation in a magnetic resonance imaging (MRI) session such as ferrous metal in the body
Have a medical condition or physical impairment precluding the ability to complete the required testing
Are pregnant
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What Are the Treatments Tested in This Trial?

Interventions

  • Transcranial Magnetic Stimulation

Trial Overview

The study is testing transcranial magnetic stimulation (TMS), a non-invasive technique that uses magnetic fields to stimulate specific areas of the brain, to see if it can improve arm and hand movement in people with cerebellar disorders.

How Is the Trial Designed?

3

Treatment groups

Experimental Treatment

Placebo Group

Group I: Parietal Brain StimulationExperimental Treatment1 Intervention
Group II: Cerebellar brain stimulationExperimental Treatment1 Intervention
Group III: Parietal Midline Brain stimulationPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

George Wittenberg

Lead Sponsor

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