Total Knee Replacement for Osteoarthritis

This trial explores the long-term performance of different knee replacement systems for individuals with osteoarthritis, a condition causing joint pain and stiffness. It evaluates how well these knee implants perform over time, focusing on patient experiences and X-ray results. Participants may receive one of four knee systems, including the Physica Cruciate Retaining Knee System, each designed to meet various needs during total knee replacement surgery. Suitable candidates have osteoarthritis or similar joint issues and are considering a total knee replacement. As an unphased trial, this study offers patients the chance to contribute to valuable research that could enhance future knee replacement options.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research shows that the Physica knee systems are safe and achieve high patient satisfaction. Studies on the Physica Kinematic Retaining Knee System report a 99.4% success rate, indicating that almost all implants functioned well without needing replacement. Patients experienced significant improvements in knee function and pain relief.

The Physica Cruciate Retaining Knee System and its version with an LMC Liner have demonstrated similar positive outcomes. Patients reported less pain and improved movement after receiving the implant.

Early studies on the Physica Posterior Stabilized Knee System indicate good performance, with many patients returning to activities they enjoyed before their knee issues. The research suggests these systems are well-tolerated, with no major safety concerns.

Researchers are excited about these Physica knee systems because they offer tailored solutions for total knee replacement in osteoarthritis patients. Unlike traditional knee implants, the Physica Cruciate Retaining (CR) System and its variant with LMC Liner are designed to preserve the knee's natural ligaments, potentially enhancing stability and function. The Physica Kinematic Retaining (KR) System aims to mimic the natural movement of the knee, providing a more natural feel for patients. Meanwhile, the Physica Posterior Stabilized (PS) System offers increased stability for those who need it. Each option provides a unique approach to addressing the specific needs of patients, potentially leading to better outcomes and greater satisfaction.

Research shows that the different Physica knee systems studied in this trial hold promise for people with osteoarthritis. Participants may receive the Physica Cruciate Retaining Knee System, which studies reveal significantly improves knee function, leading to better patient outcomes. Another option is the Physica Kinematic Retaining Knee System, which also demonstrates impressive improvements and a 99.4% success rate, indicating that most implants last long without needing replacement. Participants may also receive the Physica Posterior Stabilized Knee System, for which results indicate good patient-reported outcomes and functional performance. Overall, these systems receive positive feedback for enhancing knee function and patient satisfaction.¹²⁴⁶⁷