Personalized Theta-burst Stimulation for Approach/Avoidance Conflict

This trial tests a new type of brain stimulation called personalized theta-burst stimulation (TBS) to determine its effect on reactions in approach/avoidance situations. The researchers aim to discover if a single session of this treatment can lead to lasting changes in behavior and brain activity. The trial will compare different TBS delivery methods, including personalized and traditional approaches. Suitable candidates have no history of chronic neurological or mental disorders and are not currently on long-term medications. As an unphased trial, this study offers a unique opportunity to contribute to cutting-edge research and potentially benefit from innovative treatment methods.

The trial excludes participants with chronic conditions that require ongoing medication, so you may not be able to participate if you need to keep taking your current medications.

Research has shown that theta-burst stimulation (TBS) is generally safe. This technique uses magnetic pulses to affect brain activity. Studies indicate that both personalized and standard TBS are well-tolerated. Some people might experience mild side effects, such as headaches or scalp discomfort, but these usually resolve quickly. Experts advise caution because TBS remains relatively new, so practitioners apply it carefully. Current research has not identified any serious negative effects of TBS on the prefrontal cortex, a part of the brain involved in complex behaviors and decision-making.¹²³⁴⁵

Researchers are excited about Personalized Theta-burst Stimulation (TBS) for approach/avoidance conflict because it offers a tailored approach to brain stimulation, unlike conventional treatments. This technique uses a figure-8 coil to deliver pulses in sync with the brain's natural rhythms, specifically targeting the prefrontal cortex and adjusting to each individual's brain activity patterns. The personalized aspect of this method distinguishes it from standard care options, which typically do not account for individual EEG activity. By potentially enhancing the brain's natural processes, this treatment could offer quicker and more efficient results, making it a promising alternative to existing therapies.

Research has shown that personalized theta-burst stimulation (TBS) can influence brain activity by targeting specific brain rhythms. TBS, a form of repetitive brain stimulation, uses a magnetic field to alter brain responses. In this trial, participants will receive various forms of TBS, including personalized TBS-EEG over the head vertex, personalized TBS-EEG over the prefrontal cortex, conventional TBS over the prefrontal cortex, and lower intensity personalized TBS-EEG. Personalizing TBS with brain rhythms measured by EEG (a test that records brain activity) may lead to lasting behavioral changes. Early findings suggest that aligning TBS with an individual's unique brain rhythm could enhance their reactions to situations, potentially reducing anxiety or hesitation in decision-making.⁶⁷⁸⁹¹⁰