Transcranial Magnetic Stimulation for Anxiety

NB
Overseen ByNicholas Balderston, PhD
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new method to treat anxiety using transcranial magnetic stimulation (TMS), which uses magnetic fields to potentially reduce anxiety symptoms. By testing different TMS methods, researchers aim to discover how these magnetic pulses can alter brain activity associated with anxiety. Right-handed individuals who speak English and have maintained a stable anxiety treatment for at least four weeks may qualify for this trial. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to innovative anxiety treatments.

Will I have to stop taking my current medications?

The trial requires that participants who are receiving therapy for anxiety must be stable on their current medication regimen for at least 4 weeks before joining. However, if you are taking medications that affect the central nervous system, you may not be eligible to participate.

What prior data suggests that transcranial magnetic stimulation is safe for anxiety treatment?

Research has shown that transcranial magnetic stimulation (TMS) is generally safe and well-tolerated. Studies indicate that side effects are usually minor and manageable. Serious side effects, such as seizures, are very rare and can be prevented with modern safety measures, with the risk of such events being less than 0.1%.

For treating anxiety, TMS is considered safe. It is non-invasive, meaning it doesn't involve surgery or medication, which reduces the risk of complications. Although TMS can sometimes increase anxiety symptoms in certain cases, this is uncommon. Overall, TMS has a strong safety record and is recommended for managing anxiety without significant negative effects.12345

Why are researchers excited about this trial?

Unlike traditional treatments for anxiety, which often involve medication or talk therapy, Transcranial Magnetic Stimulation (TMS) uses magnetic fields to stimulate nerve cells in the brain. This treatment is unique because it offers a non-invasive option that directly targets brain activity, potentially reducing anxiety symptoms without the side effects commonly associated with medication. Researchers are excited about TMS because of its promise for those who haven't found relief through standard therapies, and because it might provide faster results by directly influencing brain function.

What evidence suggests that transcranial magnetic stimulation is effective for anxiety?

Research has shown that transcranial magnetic stimulation (TMS) can greatly reduce anxiety symptoms in many people. In one study, most participants experienced a noticeable decrease in anxiety after 25 TMS sessions. Another study found a 35-40% reduction in anxiety symptoms, even for those unresponsive to other treatments. Additionally, about half of the patients reported less anxiety after at least 20 sessions, with some experiencing complete relief. This trial will evaluate the effectiveness of Active TMS compared to Sham TMS, suggesting that TMS could be an effective option for treating anxiety.26789

Who Is on the Research Team?

NB

Nicholas Balderston, PhD

Principal Investigator

University of Pennsylvania

Are You a Good Fit for This Trial?

This trial is for right-handed adults with anxiety who can give consent and, if on therapy, have been stable for at least 4 weeks. People can't join if they have major medical or neurological issues, a history of seizures or epilepsy, metal implants, are pregnant, use certain medications or substances, have hearing loss, claustrophobia, or other psychiatric conditions.

Inclusion Criteria

Able to give their consent
I have been on the same anxiety medication for at least 4 weeks.
Right-handed

Exclusion Criteria

Non-english speaking
I do not have any serious medical or neurological conditions.
I have a higher risk of having seizures.
See 12 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Baseline Assessment

Participants undergo baseline assessments including anxious arousal, resting state functional connectivity, and TMS-evoked BOLD responses

1 week
1 visit (in-person)

Treatment

Participants receive 600 pulses of cTBS or sham stimulation with TMS-evoked BOLD responses recorded before and after the intervention

5 weeks
4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including anxiety potentiated startle and TMS-evoked BOLD responses

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Active TMS
  • Sham TMS

Trial Overview

The study compares two types of transcranial magnetic stimulation (TMS) to the brain: an active TMS treatment and a sham (placebo-like) TMS. The goal is to see how these affect brain activity and anxiety symptoms using MRI scans.

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Transcranial Magnetic StimulationExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials
2,118
Recruited
45,270,000+

Citations

Transcranial magnetic stimulation for the treatment of anxiety ...

Most participants who received treatment from 25 rTMS sessions had a clinically significant decrease in anxiety symptoms as identified by the efficacy symptom ...

The impact of repetitive transcranial magnetic stimulation ...

A growing body of clinical evidence consistently supports the efficacy of rTMS in reducing anxiety symptoms. Moreover, certain stimulation parameters—such as ...

Does TMS Work for Anxiety? (What the Research Says)

The length of therapy depends on the type and severity of the symptoms, with many patients seeing significant improvement after 8–16 weeks of ...

Repetitive Transcranial Magnetic Stimulation for Generalized ...

Collectively, the results suggest that TMS treatment for GAD reduced anxiety scores across all populations. Transcranial magnetic stimulation (TMS) in adults ...

5.

pubmed.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov/40974751/

Effectiveness and safety of repetitive transcranial magnetic ...

Conclusion: The rTMS could be an effective and safe treatment for patients with GAD. However, these findings should be interpreted with caution due to high ...

Sarah H. Lisanby: Transcranial Magnetic Stimulation Safety ...

The safety profile of TMS is excellent. The common side effects tend to be minor and are easily managed. The serious side effects are rare and can be prevented ...

Transcranial magnetic stimulation

Transcranial magnetic stimulation (TMS) is a procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of major depression.

Efficacy and safety of repetitive transcranial magnetic ... - PMC

The treatment had beneficial effects in the rTMS group compared with the control group in mean anxiety score (SMD=−0.68; 95% CI −0.89 to −0.46). None of the 21 ...

Can TMS Make Anxiety Worse? Addressing Patient ...

TMS rarely increases or triggers anxiety symptoms in most patients. However, some may experience anxiety symptoms in certain situations.