Electrical Stimulation for ALS

(MND Trial)

This trial tests whether electrical stimulation on the face can reduce jaw pain and improve chewing for people with ALS (a disease affecting nerve cells in the brain and spinal cord) and PLS (a similar condition). Participants will undergo a single 30-minute session of electrical stimulation using Transcutaneous Electrical Nerve Stimulation, which involves placing pads on the facial muscles. The trial aims to determine if this treatment can also ease oral hygiene tasks. Individuals diagnosed with ALS or PLS who frequently experience jaw pain are eligible to participate. As an unphased trial, this study offers a unique opportunity to explore innovative treatments that could enhance daily life for those affected by ALS and PLS.

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Research has shown that Transcutaneous Electrical Nerve Stimulation (TENS) is generally safe. Most studies find that TENS is easy to manage. The most common side effect is mild headaches, with no known negative effects on thinking or memory. This indicates the treatment is quite safe, especially since it lasts only for a single 30-minute session.

Transcutaneous Electrical Nerve Stimulation (TENS) is unique because it offers a non-invasive way to potentially reduce facial pain and improve jaw mobility in individuals with ALS and PLS. Unlike standard treatments, which often include medications to manage symptoms, TENS uses electrical impulses to stimulate nerves, aiming to improve muscle function and reduce discomfort. Researchers are excited about this technique because it could provide a safer and potentially quicker alternative to managing facial pain without relying on medication.

Research has shown that transcutaneous electrical nerve stimulation (TENS) can reduce pain and improve muscle function. Studies have found that TENS significantly lessens movement problems in people with ALS, potentially aiding mobility and reducing pain. Some evidence also suggests it eases muscle tightness and enhances overall comfort. In this trial, all participants will receive TENS to evaluate its potential in making activities like chewing and moving the jaw easier and less painful for those with ALS and Primary Lateral Sclerosis (PLS).¹²³⁶⁷