60 Participants NeededMy employer runs this trial

Music for Alzheimer's and Dementia

(Music4Pain Trial)

AA
AL
Overseen ByAZA Lab
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores how group drumming sessions might affect pain and brain function in individuals with early Alzheimer's, mild dementia, or mild cognitive impairment (MCI). Researchers aim to determine if drumming can influence heart rate, brain activity, and overall pain levels. Participants will either join drumming or music-listening sessions over ten weeks, with various measurements taken before and after. Ideal participants have experienced chronic pain for over three months, affecting their daily tasks, and are willing to engage in activities such as wearing a heart monitor and completing surveys. As an unphased trial, this study provides a unique opportunity to explore innovative non-drug therapies for cognitive and pain management.

Do I have to stop taking my current medications for the trial?

The trial may require you to stop taking certain medications, especially those affecting the central nervous system, as they might interfere with study measurements. It's best to discuss your current medications with the trial team to see if any adjustments are needed.

What prior data suggests that these music-based interventions are safe for individuals with Alzheimer's and dementia?

In a previous study, researchers found that group drumming can safely and effectively encourage exercise and improve health, thinking, and memory in older adults, including those with dementia. Participants reported no major negative effects during these sessions. Another study showed that rhythmic musical activities, like drumming, improved mood and reaction time without causing harm.

For music-listening sessions, research shows that listening to music can boost mood and may help slow memory loss in people with mild cognitive impairment (MCI) or dementia. Music therapy has been linked to a lower risk of dementia and cognitive decline, with studies showing no harmful side effects from these sessions.

Overall, both group drumming and music-listening sessions appear to be well-tolerated activities with no significant negative effects reported. These activities are generally considered safe for people with Alzheimer's, dementia, or MCI.12345

Why are researchers excited about this trial?

Researchers are excited about using music as a treatment for Alzheimer's and dementia because it offers a non-pharmacological approach that targets emotional and social engagement. Traditional treatments often rely on medications to manage symptoms, but group drumming and music-listening sessions aim to enhance brain activity and cognition through active participation and emotional connection. This approach could potentially improve mood, reduce pain sensitivity, and boost communication skills, offering a holistic alternative that complements existing therapies.

What evidence suggests that group drumming and music-listening sessions could be effective for Alzheimer's and dementia?

Research has shown that group drumming, which participants in this trial may experience, can enhance thinking skills and mood in older adults, including those with mild memory problems or dementia. Studies found that individuals who participated in drumming sessions performed better on tests, answering more questions correctly. These sessions also boost mood and keep the brain active. Similarly, listening to music, another treatment option in this trial, has improved memory and language skills and reduced stress in people with mild memory issues. Both drumming and music therapy offer promising non-drug methods to support brain health and well-being.23467

Who Is on the Research Team?

AA

AZA Allsop, MD, PhD

Principal Investigator

Yale University

Are You a Good Fit for This Trial?

This trial is for people with early Alzheimer's, mild dementia, or mild cognitive impairment who have ongoing non-cancer pain lasting over 3 months and affects daily life. Caregivers of such individuals can also join. Participants must be able to consent and willing to take part in various tests and recordings.

Inclusion Criteria

* Able to provide informed consent
* Clinical Dementia Rating 0.5 - 2
* Willing to wear an EEG headset and heart rate monitoring devices
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo deep phenotyping of pain using QST, blood sampling, brain activity recordings, and psychometric assessments

1 week
1 visit (in-person)

Intervention

Participants engage in weekly drumming sessions or music-listening activities, with heart data and psychometric surveys collected

8 weeks
8 visits (in-person)

Post-Intervention Assessment

Participants undergo post-intervention assessments including physiological, bloodwork, communication/language, pain sensitivity, and survey data collection

1 week
1 visit (in-person)

Follow-up

Participants are monitored for changes in pain perception, brain activity, and psychological symptoms

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Group Drumming
  • Music-listening session

Trial Overview

The study compares group drumming sessions with music-listening sessions to see how they affect pain levels, brain activity, heart rate, and mood in people with memory problems or their caregivers over an 8-week period.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Group I: AD / Dementia / MCI participants without chronic pain and caregivers dyadsExperimental Treatment1 Intervention
Group II: AD / Dementia / MCI participants with chronic pain and caregivers dyadsExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Yale University

Lead Sponsor

Trials
1,963
Recruited
3,046,000+

NeuroArts Blueprint Initiative

Collaborator

National Center for Complementary and Integrative Health (NCCIH)

Collaborator

Trials
886
Recruited
677,000+

Renée Fleming Foundation

Collaborator

Yale University School of Medicine, Department of Psychiatry

Collaborator

Howard University

Collaborator

Trials
44
Recruited
15,200+

Citations

Drum Communication Program Intervention in Older Adults ...

The intervention group exhibited improved cognitive function and upper limb motion range, and changes in body composition. The results suggest ...

Study Details | NCT07602283 | Music for Pain and Dementia

This study aims to provide mechanistic insights into how group drumming as a music-based intervention (MBI) affects pain responses and ...

Rhythmic musical intervention improves response time ... - PMC

This pilot study investigated the potential benefits of rhythmic musical intervention, African drumming, on cognitive function and mood status

Effects of Drumming-Based Cognitive and Physical ...

As such, drumming-based cognitive training may serve as an effective non-pharmacological tool for preventing or mitigating age-related cognitive decline. Author ...

Effects of group music sessions on cognitive and ...

These findings indicated that group music sessions have a potentially beneficial effect for maintaining and improving cognitive and psychological functions in ...

Association between upper limb movements during drumming ...

We developed a new method using drums to measure upper limb motor function in people with dementia. We also verified that the average arm elevation angle ...

Rhythmic Musical Intervention Improves Short‐term Memory ...

After 8 sessions of African drum intervention, the cognitive function did not show significant improvement (p = 0.108), but the response time of ...