Transcranial Magnetic Stimulation for Alcoholism

(TMS Trial)

This trial explores the use of transcranial magnetic stimulation (TMS), a non-invasive technique that affects brain activity, to help treat alcohol use disorder (AUD). Researchers aim to understand how TMS impacts brain circuits involved in AUD, hoping to find new management strategies for this condition. Participants will receive different combinations of TMS, including some sessions with inactive (sham) treatment for comparison. The trial seeks individuals who either consume a lot of alcohol or do not drink heavily at all. As an unphased trial, it offers participants the opportunity to contribute to groundbreaking research that could lead to innovative treatments for AUD.

The trial requires that participants do not take medications known to affect alcohol intake or craving, and those that lower the seizure threshold. If you are on such medications, you may need to stop taking them to participate.

Research has shown that Transcranial Magnetic Stimulation (TMS) is generally safe and well-tolerated for individuals with substance use disorders, including alcohol use disorder. Most experience only mild side effects, with headaches being the most common, which typically resolve on their own. Although there is a small risk of seizures, this remains rare. Studies indicate that the side effects of TMS in people with substance use issues resemble those in other groups, suggesting the treatment is manageable for most participants.¹²³⁴⁵

Researchers are excited about using Transcranial Magnetic Stimulation (TMS) for treating alcoholism because it offers a unique, non-invasive approach by directly stimulating specific regions of the brain. Unlike traditional treatments for alcoholism, which often involve medications like disulfiram or naltrexone that work by modifying the brain's chemical signals or reducing cravings, TMS targets the brain's neural activity through magnetic fields. This method could potentially provide quicker results with fewer side effects, making it a promising alternative for individuals who haven't responded well to standard treatments. Additionally, the trial explores different protocols, including variations in frequency and sequence of stimulation, which could help tailor the therapy to individual needs and optimize its effectiveness.

Research has shown that transcranial magnetic stimulation (TMS), which participants in this trial may receive, can help reduce cravings and alcohol use in people with alcohol use disorder (AUD). Studies have found that TMS may lower the number of days people drink heavily. It uses magnetic fields to alter brain activity, affecting cravings and impulsive behavior. Some research also suggests that TMS can improve brain structure and function related to AUD. Overall, TMS is considered a promising tool for reducing alcohol consumption and cravings.²⁶⁷⁸⁹