CARRII Native for Alcohol-Exposed Pregnancy

This trial aims to identify the best combination of online tools to reduce alcohol-exposed pregnancies among Native women and others who can become pregnant. It focuses on enhancing the CARRII Native, an online program, to increase its effectiveness and affordability for Native communities. Participants will test various combinations of new intervention components, known as CARRII Native Cores, to determine the most effective approach. Suitable candidates have reported risky alcohol consumption and potential pregnancy in the last 90 days, have internet access on a mobile device, and are Native American, American Indian, or Alaska Native. As an unphased trial, this study provides a unique opportunity to contribute to the development of innovative tools that could significantly benefit Native communities.

The trial information does not specify whether you need to stop taking your current medications.

Research has shown that the CARRII Native Cores, an online tool to help reduce the risk of alcohol-exposed pregnancy, is generally well-received. One study found that users experienced mild side effects. This digital tool assists Native American women and others who can become pregnant in managing alcohol use and related behaviors. The tool aims to be safe and effective, and previous research supports that most users find the side effects manageable.¹²³⁴⁵

Researchers are excited about the CARRII Native Cores trial because it explores new intervention components for pregnancies affected by alcohol exposure. Unlike existing treatments that may focus on managing symptoms or providing general support, this approach looks at specific combinations of components labeled A, B, and C, which have the potential to target the condition more precisely. By experimenting with different combinations, such as A and C or A, B, and C together, researchers hope to uncover more effective strategies to support healthy pregnancy outcomes in cases of alcohol exposure. This kind of tailored approach could lead to more personalized and effective care options in the future.

Research has shown that the CARRII Native program may help reduce the risk of pregnancies affected by alcohol. One study reported a noticeable decrease in unprotected sex among participants, from 88.9% before the program to 70.6% after. This improvement persisted over time, indicating lasting benefits. Additionally, a nationwide pilot study found that CARRII was more effective than a standard education program in lowering the risk of alcohol-exposed pregnancies. This trial will evaluate various intervention components of the CARRII Native program, such as components A, B, and C, to determine their effectiveness. These findings suggest that CARRII can be a useful tool for reducing this risk, especially for Native women and those who can become pregnant.³⁴⁶⁷⁸