Pharmacist-Led Lipid Optimization for High Cholesterol
(EHR-LOCALE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to determine whether a proactive, EHR-guided approach helps more individuals reach safe cholesterol levels, improves medication use, and reduces future heart attacks and strokes, compared to usual care.
The main question it aims to answer is:
• Does the EHR-LOCALE pathway increases the proportion of patients who reach the LDL-cholesterol target of \<1.8 mmol/L at 6 months?
Participants in the interventional group receive:
* Pharmacist contact
* Repeat lipid requisitions
* Review of medications, adherence, and side effects
* Treatment escalation according to national dyslipidemia guidelines
Who Is on the Research Team?
Pishoy Gouda, MD
Principal Investigator
University of Alberta
Are You a Good Fit for This Trial?
This trial is for adults in Alberta who have been hospitalized for a heart problem like a heart attack and had a coronary angiogram. Participants must be over 18 and able to take part in follow-up if chosen for the intervention.Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- Pharmacist-led lipid optimization pathway
Trial Overview
The study tests whether regular pharmacist support, medication reviews, and lab checks—guided by electronic health records—help people reach safer cholesterol levels compared to usual care after a serious heart event.
How Is the Trial Designed?
2
Treatment groups
Active Control
Participants in the usual care arm will have data collected (baseline demographics, medical history, laboratory values, medication usage and clinical outcomes) from their health record. Usual care will include follow-up with their primary cardiologist, primary care physician, cardiac rehabilitation team and community pharmacy as per standards of care across Canada and the CCS Dyslipidemia Guidelines. This data will include information regarding their cholesterol levels and cholesterol treatments received as per standard of care practices.
Participants in the intervention will provide verbal consent to participate. In addition to data collection, Pharmacist contact will occur monthly until their cholesterol levels at target or if they no longer wish to participate in the study, no further changes in medications will occur and no further follow-up is required. Participation in the interventional arm can last up to 6 months.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alberta
Lead Sponsor
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